A novel “humanized mouse” model for autoimmune hepatitis and the association of gut microbiota with liver inflammation
Yuksel M, Wang Y, Tai N, Peng J, Guo J, Beland K, Lapierre P, David C, Alvarez F, Colle I, Yan H, Mieli-Vergani G, Vergani D, Ma Y, Wen L. A novel “humanized mouse” model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. Hepatology 2015, 62: 1536-1550. PMID: 26185095, PMCID: PMC4763614, DOI: 10.1002/hep.27998.Peer-Reviewed Original ResearchConceptsAnti-liver cytosol type 1 autoantibodiesAnti-liver kidney microsomal type 1Autoimmune hepatitisHLA-DR3Type 1Antigenic targetsAntinuclear autoantibodiesAnti-liver cytosol type 1T helper 1 immune responseHelper 1 immune responsePathogenesis of AIHSevere inflammatory liver diseaseTypes of AIHHLA-DR3 transgenic miceAnti-smooth muscleInflammatory liver diseaseAssociation of HLANonobese diabetic (NOD) miceRegulatory T cellsImmune cell infiltrationNovel mouse modelNonobese diabetic (NOD) backgroundHumanized animal modelsFormiminotransferase cyclodeaminaseAIH-1Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs
Hu Y, Peng J, Tai N, Hu C, Zhang X, Wong FS, Wen L. Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs. The Journal Of Immunology 2015, 195: 4176-4184. PMID: 26401004, PMCID: PMC4765177, DOI: 10.4049/jimmunol.1500884.Peer-Reviewed Original ResearchConceptsNOD miceTolerogenic APCsDiabetes developmentT cell-mediated autoimmune diseaseDiabetogenic CD8 T cellsCell-mediated autoimmune diseasePolymyxin BCD8 T cellsNonobese diabetic (NOD) miceType 1 diabetesHost immune systemIslet β-cellsAutoimmune diabetesDifferent time pointsImmune toleranceDiabetic miceAutoimmune diseasesProfound protectionT cellsImmune responseProtective effectCommensal microbiotaGut microbiotaSusceptible individualsCommensal bacteria