2013
TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic Mice
Tai N, Wong FS, Wen L. TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic Mice. The Journal Of Immunology 2013, 191: 2926-2937. PMID: 23956420, PMCID: PMC3788667, DOI: 10.4049/jimmunol.1300547.Peer-Reviewed Original ResearchConceptsNOD miceCD73 expressionT cellsTLR9 deficiencyDiabetes developmentImmune cellsAnti-inflammatory cytokine productionImproved β-cell functionImportant immune regulatory roleStrong immunosuppressive functionNonobese diabetic (NOD) miceIncidence of diabetesNOD mouse modelPeripheral lymphoid tissuesImmune regulatory roleType 1 diabetesΒ-cell functionNew therapeutic strategiesElevated frequencyNOD backgroundDiabetes protectionDiabetic miceImmunosuppressive functionProinflammatory cytokinesCytokine production
2012
B cell depletion - a double-edged sword (123.18)
Tai N, Wen L. B cell depletion - a double-edged sword (123.18). The Journal Of Immunology 2012, 188: 123.18-123.18. DOI: 10.4049/jimmunol.188.supp.123.18.Peer-Reviewed Original ResearchB-cell depletionCell depletionT cellsB cellsDay 3B cell depletion therapyAdoptive transfer approachEffector T cellsNOD mouse modelT cell effectorsT cell subsetsSingle-dose injectionSecondary lymphoid organsSplenic T cellsWeek old miceMultiple T cellsRAG miceDepletion therapySplenic CD4ICOS expressionCD4-CD8Control miceAutoimmune diseasesCell subsetsLymphoid organs