2006
Bayesian error analysis model for reconstructing transcriptional regulatory networks
Sun N, Carroll RJ, Zhao H. Bayesian error analysis model for reconstructing transcriptional regulatory networks. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 7988-7993. PMID: 16702552, PMCID: PMC1472417, DOI: 10.1073/pnas.0600164103.Peer-Reviewed Original ResearchConceptsTranscriptional regulatory networksGene expression dataTranscription regulationRegulatory networksExpression dataProtein-DNA binding dataDNA sequence dataFundamental biological processesYeast cell cycleHigh-throughput technologiesMicroarray gene expression dataBiological experimentsSequence dataGenomic dataBiological processesCell cycleClear biological interpretationThroughput technologiesBiological interpretationMarkov chain Monte CarloBayesian hierarchical model frameworkBiochemical reactionsRegulationLinear system modelHierarchical model framework
2004
Genomic approaches in dissecting complex biological pathways
Sun N, Zhao H. Genomic approaches in dissecting complex biological pathways. Pharmacogenomics 2004, 5: 163-179. PMID: 15016608, DOI: 10.1517/phgs.5.2.163.27488.Peer-Reviewed Original ResearchConceptsNetwork modelScale-free network modelDifferent genomic dataBoolean network modelDifferential equationsScale-free propertyMathematical modelBayesian network modelLarge-scale genomic dataGeneral network propertiesLarge-scale dataData integration methodIntegration methodGenomic dataLocal propertiesComputational methodsNetwork motifsData typesNetwork propertiesRich informationPrior knowledgeDifferent modelsRigorous comparisonEquationsMajor methodologies