2022
Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II
Shawky NM, Dalmasso C, Ojeda NB, Zuchowski Y, Stachenfeld N, Alexander BT, Reckelhoff JF. Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II. Journal Of Hypertension 2022, 40: 712-722. PMID: 34980865, PMCID: PMC8897268, DOI: 10.1097/hjh.0000000000003067.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeAttenuated pressor responsesPressor responseBlood pressureAng IIHyperandrogenemic femalesAngiotensin IIFemale offspringModel of PCOSNitrate/nitrite excretionSimilar baseline blood pressureIntrarenal Ang IIBaseline blood pressureElevated blood pressureExaggerated pressor responseHigh-salt dietLow birth weightFemale control offspringDihydrotestosterone pelletsMaternal hyperandrogenemiaMore proteinuriaPCOS womenOvary syndromeRenal injurySalt diet
2020
Autonomic Dysfunction in Women with Androgen Excess PCOS
Stone T, Leone C, Ayers T, Stachenfeld N. Autonomic Dysfunction in Women with Androgen Excess PCOS. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.01846.Peer-Reviewed Original ResearchLower body negative pressurePolycystic ovary syndromeForearm vascular resistanceGnRH-antBlood pressureBaroreflex sensitivityEstrogen suppressionBRS slopeHormone suppressionAutonomic functionElevated blood pressureReproductive-age womenBody negative pressureTestosterone-induced changesAutonomic dysfunctionMild hypertensionVascular resistanceObese womenOvary syndromeGnRH antagonistAge womenBP regulationCardiovascular diseaseReproductive endocrinopathyBiochemical manifestations
2018
Blood Pressure Predicts Endothelial Function and Effect of Ethinyl Estradiol in Young Obese and Lean Women
Adler T, Usselman C, Takamata A, Stachenfeld N. Blood Pressure Predicts Endothelial Function and Effect of Ethinyl Estradiol in Young Obese and Lean Women. The FASEB Journal 2018, 32: 713.3-713.3. DOI: 10.1096/fasebj.2018.32.1_supplement.713.3.Peer-Reviewed Original ResearchElevated blood pressureHigh blood pressureBlood pressureEndothelial functionEthinyl estradiol treatmentEndothelial dysfunctionFMD responseHealthy womenEstradiol treatmentAmerican Heart Association guidelinesNew American Heart Association guidelinesIschemic handgrip exerciseHeart Association guidelinesYoung healthy womenFull-text articlesShear stress stimulusRH-FMDMild hypertensionHandgrip exerciseLean womenVasodilatory responseHyperemic responseAssociation guidelinesCardiovascular diseaseEthinyl estradiol