2023
Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BP
2021
Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS
Stone T, Chiles M, Leone C, Pal L, Stachenfeld N. Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.04149.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityLower body negative pressureSympathetic baroreflex sensitivityPolycystic ovary syndromeBaroreflex sensitivityBR controlDiastolic BPHormone suppressionImpaired blood pressure regulationGonadotropin-releasing hormone antagonistOral glucose tolerance testDays of GnRHSympathetic nerve activityInsulin-resistant womenMean arterial pressureVascular resistance changesReproductive-age womenGlucose tolerance testBody negative pressureBlood pressure regulationSuppression of E2Bursts/100 heartbeatsCardiovascular comorbiditiesPCOS phenotypeResistant women