2024
The effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis
Colburn A, Leone C, Alexander L, Stachenfeld N. The effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis. Physiology 2024, 39: 421. DOI: 10.1152/physiol.2024.39.s1.421.Peer-Reviewed Original ResearchEndothelium-dependent vasodilationEstrogen suppressionHealthy controlsLDF/mean arterial pressureSodium nitroprusside perfusionDose-response curveLaser Doppler flowmetryCardiovascular disease riskCutaneous vascular conductanceACh doseEndometriosis patientsPerfusion of acetylcholineMenstrual cycleIntradermal microdialysisSuppress estrogenEndothelial functionArterial pressureEndometriosisVasodilatory functionDoppler flowmetryVascular conductanceVasodilationMaximal vasodilationGraded perfusionEstrogenInhibition of NF-κB Activation Improves Non-Nitric Oxide-Mediated Cutaneous Microvascular Function in Reproductive-Aged Healthy Women
Content V, Williams A, Stachenfeld N, Alexander L. Inhibition of NF-κB Activation Improves Non-Nitric Oxide-Mediated Cutaneous Microvascular Function in Reproductive-Aged Healthy Women. Physiology 2024, 39: 562. DOI: 10.1152/physiol.2024.39.s1.562.Peer-Reviewed Original ResearchInhibition of NF-kB activationCutaneous microvascular functionNF-kB activationMicrovascular functionHealthy womenCutaneous vascular conductanceSalsalate treatmentInflammatory mechanismsImpact of systemic inflammationIncreasing concentrations of acetylcholineIntradermal microdialysis fibersDose-response protocolCohort of patientsMeasuring cutaneous blood flowPlacebo-controlled designHealthy control subjectsSystemic vascular functionNO synthase inhibitorHuman cutaneous circulationLaser-Doppler flowmetryDose-response curveRed blood cell fluxBlood cell fluxCardiovascular disease riskVentral forearm skin
2022
Polycystic ovary syndrome and black race are associated with increased blood pressure
Okifo N, Pal L, Mushi M, Stachenfeld N. Polycystic ovary syndrome and black race are associated with increased blood pressure. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3724.Peer-Reviewed Original ResearchOlder reproductive age womenReproductive-age womenNon-obese groupPolycystic ovary syndromeMultivariable linear regression modelsBlood pressureAge womenObese groupBlack raceBP indicesOvary syndromeRacial breakdownDiagnosis of PCOSNon-obese womenCardiovascular disease riskMultivariable linear regressionType II diabetesLinear regression modelsGreater systolicTubal infertilityIndependent predictorsCommon endocrinopathyRegression modelsBP measurementsPCOS
2018
Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan
Stanhewicz AE, Wenner MM, Stachenfeld NS. Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan. AJP Heart And Circulatory Physiology 2018, 315: h1569-h1588. PMID: 30216121, PMCID: PMC6734083, DOI: 10.1152/ajpheart.00396.2018.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelial functionHealthy young womenCardiovascular diseaseVascular healthSex hormonesCardiovascular systemOverall cardiovascular disease riskSex differencesYoung womenAge-associated endothelial dysfunctionRenin-angiotensin systemPredictor of atherosclerosisAtherosclerotic cardiovascular diseaseCardiovascular disease riskCause of morbidityMale sex hormonesReceptor-independent mechanismVascular endothelinCVD riskEndothelial dysfunctionAge-related declineEarly decrementsFemale hormonesSimilar age-related declineCVD increases
2017
Relationship between body mass index and endothelial dysfunction in women with and without polycystic ovary syndrome
Adler T, Usselman C, Anaeto L, Schapiro R, Steele F, Toffoloni N, Takamata A, Taylor H, Stachenfeld N. Relationship between body mass index and endothelial dysfunction in women with and without polycystic ovary syndrome. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.691.8.Peer-Reviewed Original ResearchPolycystic ovary syndromeEndothelial dysfunctionOvary syndromeFlow-mediated dilation responseSympathetic nervous system activationCardiovascular disease riskBody mass indexFlow-mediated dilation (FMD) testAmerican Heart AssociationMinutes of occlusionNervous system activationRotterdam criteriaFMD responseBrachial arteryEndothelial functionEndothelial healthHealthy womenHyperemic responseMass indexSuprasystolic pressureControl womenHeart AssociationInsulin resistanceClinical indicesReproductive age