2012
Blood pressure and water regulation: understanding sex hormone effects within and between men and women
Wenner MM, Stachenfeld NS. Blood pressure and water regulation: understanding sex hormone effects within and between men and women. The Journal Of Physiology 2012, 590: 5949-5961. PMID: 23027816, PMCID: PMC3530109, DOI: 10.1113/jphysiol.2012.236752.Peer-Reviewed Original ResearchConceptsOvarian hormone exposureBlood pressureHormone exposureHormone effectsYoung womenOvarian hormone effectsSuppress reproductive functionBlood pressure controlFirst-line treatmentSex differencesEffects of estrogenPlasma volume expansionCause of deathSex hormone effectsBody fluid regulationGreater morbidityHealthy womenLine treatmentOvarian hormonesMenopausal womenBody water balanceOrthostatic toleranceProgesterone exposureMenstrual cycleHormone administration
2001
Progesterone does not alter osmotic regulation of AVP
Calzone W, Silva C, Keefe D, Stachenfeld N. Progesterone does not alter osmotic regulation of AVP. AJP Regulatory Integrative And Comparative Physiology 2001, 281: r2011-r2020. PMID: 11705788, DOI: 10.1152/ajpregu.2001.281.6.r2011.Peer-Reviewed Original ResearchConceptsHypertonic saline infusionLuteal phaseOral contraceptivesFollicular phaseOsmotic thresholdThirst onsetRenal free water clearanceLow osmotic thresholdFree water clearancePlasma AVP concentrationArginine vasopressin releaseBaseline plasma osmolalityBody water balanceMenstrual cycleMidluteal phaseWater clearanceSaline infusionAVP releaseAVP concentrationMenstrual phaseVasopressin releaseFluid balanceOC treatmentThirst responseCrossover designHormonal Contraception, Body Water Balance and Thermoregulation
Stachenfeld N. Hormonal Contraception, Body Water Balance and Thermoregulation. 2001 DOI: 10.21236/ada410450.Peer-Reviewed Original ResearchLuteal phaseEstrogen/progestinExercise-induced dehydrationCross-over designOral contraceptivesSodium retentionHormonal contraceptionBody water balanceFollicular phaseHypertonic salineMidluteal phaseMenstrual cycleHormonal effectsSodium regulationProgestinsBody waterExerciseContraceptivesEstrogenContraceptionPAVPSaline
1999
Effects of oral contraceptives on body fluid regulation
Stachenfeld N, Silva C, Keefe D, Kokoszka C, Nadel E. Effects of oral contraceptives on body fluid regulation. Journal Of Applied Physiology 1999, 87: 1016-1025. PMID: 10484572, DOI: 10.1152/jappl.1999.87.3.1016.Peer-Reviewed Original ResearchConceptsBody fluid regulationLuteal phaseHighest plasma estradiol concentrationFluid regulationOral contraceptive administrationBody fluid retentionPlasma estradiol concentrationsMidluteal menstrual phasesBody fluid balanceArginine vasopressin concentrationBasal plasma osmolalityExercise dehydrationOral contraceptivesContraceptive administrationBody water balanceFluid retentionFollicular phaseEstradiol concentrationsAVP releaseMenstrual phaseFluid balanceVasopressin concentrationCrossover designThirst stimulationPlasma osmolality
1998
Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women
Stachenfeld N, Dipietro L, Palter S, Nadel E. Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. American Journal Of Physiology 1998, 274: r187-r195. PMID: 9458917, DOI: 10.1152/ajpregu.1998.274.1.r187.Peer-Reviewed Original ResearchConceptsMin of drinkingPg/Body water balanceHypertonic salineFractional sodium excretionPlasma aldosterone concentrationRenal sodium reabsorptionFree water clearancePlasma estradiol concentrationsHypertonic saline infusionHigh E2 statesWater ad libitumMosmol/kgH2OAldosterone concentrationPostmenopausal womenSodium excretionPlacebo administrationUrine outputAVP secretionSodium reabsorptionFluid retentionE2 treatmentEstradiol concentrationsWater clearanceSaline infusion