2021
Granulocyte Colony-Stimulating Factor Is Safe and Well Tolerated following Allogeneic Transplantation in Patients with Sickle Cell Disease
Shah NC, Bhoopatiraju S, Abraham A, Anderson E, Andreansky M, Bhatia M, Chaudhury S, Cuvelier GDE, Godder K, Grimley M, Hale G, Kamani N, Jacobsohn D, Ngwube A, Gilman AL, Skiles J, Yu LC, Shenoy S. Granulocyte Colony-Stimulating Factor Is Safe and Well Tolerated following Allogeneic Transplantation in Patients with Sickle Cell Disease. Transplantation And Cellular Therapy 2021, 28: 174.e1-174.e5. PMID: 34958973, DOI: 10.1016/j.jtct.2021.12.016.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationSickle cell diseaseNeutrophil recoveryG-CSFCell diseaseReduced-intensity conditioning hematopoietic stem cell transplantationReversible posterior leukoencephalopathy syndromeCalcineurin inhibitor therapyHemoglobin S levelPosterior leukoencephalopathy syndromeLife-threatening complicationsG-CSF useGranulocyte-colony stimulating factorStem cell infusionStem cell transplantationGranulocyte colony-stimulating factorG-CSF initiationAvailable stem cell sourceStem cell sourceColony-stimulating factorLeukoencephalopathy syndromeSickle vasculopathyHSCT recipientsNeutrophil engraftmentPlatelet engraftment
2020
Granulocyte Colony-Stimulating Factor Is Safe and Well Tolerated Following Allogeneic Transplantation in Patients with Sickle Cell Disease
Shah N, Bhoopatiraju S, Abraham A, Anderson E, Andreansky M, Bhatia M, Chaudhury S, Cuvelier G, Godder K, Grimley M, Hale G, Kamani N, Jacobsohn D, Ngwube A, Skiles J, Yu L, Shenoy S. Granulocyte Colony-Stimulating Factor Is Safe and Well Tolerated Following Allogeneic Transplantation in Patients with Sickle Cell Disease. Blood 2020, 136: 33. DOI: 10.1182/blood-2020-142696.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseAbsolute neutrophil countVaso-occlusive episodesG-CSF administrationNeutrophil recoveryG-CSFSCD patientsCell diseaseDay 100Unrelated donor hematopoietic cell transplantationDonor hematopoietic cell transplantationVaso-occlusive pain crisesHemoglobin S levelPrimary graft rejectionShort-course methotrexateAcute chest syndromeLife-threatening complicationsG-CSF useGranulocyte-colony stimulating factorGranulocyte colony-stimulating factorTranscranial Doppler velocitiesDifferent donor sourcesColony-stimulating factorSafety/toxicity