2022
L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities
Nunes E, Addy N. L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities. Neuropharmacology 2022, 224: 109336. PMID: 36414149, PMCID: PMC11215796, DOI: 10.1016/j.neuropharm.2022.109336.Peer-Reviewed Original ResearchConceptsL-type calcium channelsVentral tegmental areaPre-clinical modelsTegmental areaSubstance useLTCC blockersMood disordersCalcium channelsCo-morbid psychiatric diagnosesDA neuronal activityVoltage-gated calcium channelsMood-related behaviorsSubstance use disordersCalcium channel regulationStress-induced plasticityAccumbens pathwayCardiac medicationsDopamine neuronsLTCC subtypesNeuronal activityNeuronal firingUse disordersPsychiatric diagnosisCalcium entryDopamine activity
2016
Chapter 38 Clinical Syndromes of Substance Use Disorder
Addy N, Solecki W. Chapter 38 Clinical Syndromes of Substance Use Disorder. 2016, 619-634. DOI: 10.1016/b978-0-12-800105-9.00038-x.Peer-Reviewed Original ResearchSubstance use disordersUse disordersGenetic adaptationEpigenetic processesGenetic mechanismsDrug-mediated changesSpecific neuronal circuitsIntracellular signalingClinical syndromeSuccessful treatmentSynaptic physiologyNeuronal circuitsCurrent understandingNeurobiological processesOngoing studiesSeminal findingsDisordersGenesSignalingSyndromePathwayPhysiologySusceptibilityNeurotransmitters