2022
L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities
Nunes E, Addy N. L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities. Neuropharmacology 2022, 224: 109336. PMID: 36414149, PMCID: PMC11215796, DOI: 10.1016/j.neuropharm.2022.109336.Peer-Reviewed Original ResearchConceptsL-type calcium channelsVentral tegmental areaPre-clinical modelsTegmental areaSubstance useLTCC blockersMood disordersCalcium channelsCo-morbid psychiatric diagnosesDA neuronal activityVoltage-gated calcium channelsMood-related behaviorsSubstance use disordersCalcium channel regulationStress-induced plasticityAccumbens pathwayCardiac medicationsDopamine neuronsLTCC subtypesNeuronal activityNeuronal firingUse disordersPsychiatric diagnosisCalcium entryDopamine activityCholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders
Nunes EJ, Kebede N, Bagdas D, Addy NA. Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders. Journal Of The Experimental Analysis Of Behavior 2022, 117: 404-419. PMID: 35286712, PMCID: PMC9743782, DOI: 10.1002/jeab.747.Peer-Reviewed Original ResearchConceptsMood disordersSubstance useActivational componentsMotivated behaviorComorbid substance useMesolimbic dopamine systemDA releaseCholinergic activityCholinergic transmissionImportant neuromodulatorCholinergic dysregulationDA regulationDopamine systemDA signalingActivational aspectsDisease statesDisordersAversive stimuliPossible roleHealthy stateCholinergicAcetylcholineStimuliEtiologyIllness
2020
Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats
Nunes EJ, Rupprecht LE, Foster DJ, Lindsley CW, Conn PJ, Addy NA. Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats. Neuropharmacology 2020, 171: 108089. PMID: 32268153, PMCID: PMC7313677, DOI: 10.1016/j.neuropharm.2020.108089.Peer-Reviewed Original ResearchConceptsSucrose preference testVentral tegmental areaMuscarinic M5 receptorsCholinergic toneM5 receptorsBehavioral effectsFemale ratsDepressive-like behavioral effectsIntra-VTA infusionAnxiogenic-like effectsAcetylcholinesterase inhibitor physostigmineAnxiety-related behaviorVTA administrationCholinergic modulationCholinergic receptorsMuscarinic receptorsInhibitor physostigmineSwim testTegmental areaMale ratsMood disordersVTA infusionsFST behaviorRatsPhysostigmine
2017
Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens
Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM. Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Molecular Psychiatry 2017, 22: 1735-1745. PMID: 28194001, PMCID: PMC5555837, DOI: 10.1038/mp.2017.9.Peer-Reviewed Original ResearchMeSH KeywordsAffectAnimalsCalcium Channels, L-TypeCocaineCocaine-Related DisordersConditioning, PsychologicalDepressionDisease Models, AnimalDopamine Uptake InhibitorsGenetic Association StudiesHumansMaleMice, Inbred C57BLMice, TransgenicMotor ActivityNucleus AccumbensPost-Synaptic DensityReceptors, AMPASocial BehaviorVentral Tegmental AreaConceptsDepressive-like behaviorCav1.3 L-type Ca2L-type Ca2Receptor mechanismsCalcium-permeable α-aminoCACNA1D geneCav1.3 channelsRole of Cav1.3Depressive-like phenotypeMood-related behaviorsDepression-related phenotypesSocial behavioral deficitsNeuropsychiatric symptomsBehavioral deficitsMood disordersCP-AMPARNAc shellRodent studiesGluA1 phosphorylationHuman studiesNAc corePlace preferenceBipolar disorderPsychomotor activityCav1.3