2023
Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders
Nunes E, Addy N, Conn P, Foster D. Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders. The Annual Review Of Pharmacology And Toxicology 2023, 64: 277-289. PMID: 37552895, PMCID: PMC10841102, DOI: 10.1146/annurev-pharmtox-051921-023858.Peer-Reviewed Original ResearchCholinergic neuronsMuscarinic acetylcholine receptor subtypesDA neuron activityMidbrain DA neuronsAcetylcholine receptor subtypesMood-related disordersPotential clinical implicationsDA circuitryDA neuronsDA releaseMuscarinic receptorsCholinergic regulationReceptor subtypesDopamine systemNeuron activityClinical implicationsNeuropsychiatric disordersDopamine signalingNumerous disordersSubtypesNumerous receptorsDisordersNeuronsReceptorsPublication date
2022
Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders
Nunes EJ, Kebede N, Bagdas D, Addy NA. Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders. Journal Of The Experimental Analysis Of Behavior 2022, 117: 404-419. PMID: 35286712, PMCID: PMC9743782, DOI: 10.1002/jeab.747.Peer-Reviewed Original ResearchConceptsMood disordersSubstance useActivational componentsMotivated behaviorComorbid substance useMesolimbic dopamine systemDA releaseCholinergic activityCholinergic transmissionImportant neuromodulatorCholinergic dysregulationDA regulationDopamine systemDA signalingActivational aspectsDisease statesDisordersAversive stimuliPossible roleHealthy stateCholinergicAcetylcholineStimuliEtiologyIllness
2016
Chapter 38 Clinical Syndromes of Substance Use Disorder
Addy N, Solecki W. Chapter 38 Clinical Syndromes of Substance Use Disorder. 2016, 619-634. DOI: 10.1016/b978-0-12-800105-9.00038-x.Peer-Reviewed Original ResearchSubstance use disordersUse disordersGenetic adaptationEpigenetic processesGenetic mechanismsDrug-mediated changesSpecific neuronal circuitsIntracellular signalingClinical syndromeSuccessful treatmentSynaptic physiologyNeuronal circuitsCurrent understandingNeurobiological processesOngoing studiesSeminal findingsDisordersGenesSignalingSyndromePathwayPhysiologySusceptibilityNeurotransmitters