2020
Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice
Shi Z, Bamford IJ, McKinley JW, Devi SPS, Vahedipour A, Bamford NS. Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice. Brain Sciences 2020, 10: 903. PMID: 33255421, PMCID: PMC7760026, DOI: 10.3390/brainsci10120903.Peer-Reviewed Original ResearchL-DOPA-induced dyskinesiaL-DOPAStriatal acetylcholineDA deficiencyMovement disordersDA availabilityHypokinetic movement disordersStriatal cholinergic interneuronsHyperkinetic movement disordersDopa decarboxylase inhibitorElectrophysiological experimentsOpen field testingStriatal ChIsParkinsonian miceCholinergic interneuronsMotor dysfunctionTherapeutic optionsMotor hyperactivityParadoxical riseDA ratioMotor functionDecarboxylase inhibitorDopamine insufficiencyΒ-ARsΒ-AR
2006
362 ROLE OF ACETYLCHOLINE IN PSYCHOSTIMULANT ADDICTION.
Kumar T, Joyce J, Bamford N. 362 ROLE OF ACETYLCHOLINE IN PSYCHOSTIMULANT ADDICTION. Journal Of Investigative Medicine 2006, 54: s142. DOI: 10.2310/6650.2005.x0004.361.Peer-Reviewed Original ResearchMedium spiny neuronsWithdrawal day 1Nucleus accumbensCholinergic activationCholinergic interneuronsBasal gangliaSpiny neuronsDorsolateral striatumDay 1Striatal medium spiny neuronsAdult C57B1/6 miceCaudal nucleus accumbensChronic METH treatmentExcitatory glutamatergic projectionsWithdrawal day 10Striatal cholinergic interneuronsC-fosTreatment of miceC-Fos immunoreactivityRole of acetylcholineNumber of ChATImmediate early gene expressionChronic METHCortical terminalsGlutamate release