2010
Chapter 35 Alterations in Corticostriatal Synaptic Function in Huntington's and Parkinson's Diseases
Cepeda C, Bamford N, André V, Levine M. Chapter 35 Alterations in Corticostriatal Synaptic Function in Huntington's and Parkinson's Diseases. Techniques In The Behavioral And Neural Sciences 2010, 20: 607-623. DOI: 10.1016/b978-0-12-374767-9.00035-4.Peer-Reviewed Original ResearchMedium-sized spiny neuronsParkinson's diseaseHuntington's diseaseCorticostriatal pathwayCortico-basal ganglia-thalamocortical loopsCorticostriatal synaptic functionBasal ganglia neuronsVariety of interneuronsGenetic mouse modelsPrincipal cell typesCoordinated preDA neuronsPostsynaptic actionsMotor disturbancesGanglion neuronsSpiny neuronsCortical neuronsElectrophysiological changesMouse modelSynaptic inputsAnimal modelsEventual degenerationSynaptic functionSubsequent degenerationPD model
2009
Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease
Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS. Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease. Journal Of Neuroscience 2009, 29: 2414-2427. PMID: 19244517, PMCID: PMC2670193, DOI: 10.1523/jneurosci.5687-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgingAnalysis of VarianceAnimalsBiophysicsCadmiumCells, CulturedCerebral CortexChromosomes, Artificial, YeastCorpus StriatumDisease Models, AnimalDopamine AgentsDose-Response Relationship, DrugElectric StimulationExcitatory Amino Acid AgentsExcitatory Postsynaptic PotentialsHumansHuntington DiseaseIn Vitro TechniquesMembrane PotentialsMiceNeural PathwaysNeuronsPyridinium CompoundsQuaternary Ammonium CompoundsStatistics, NonparametricTime FactorsTrinucleotide Repeat ExpansionConceptsYAC128 mouse modelGlutamate releaseCorticostriatal pathwayHuntington's diseaseCorticostriatal activityMouse modelSynaptic currentsMedium spiny neuronsAge-dependent alterationsGenetic neurodegenerative disorderAge-dependent changesBehavioral phenotypesSpiny neuronsCortical neuronsDisease progressionReceptor modulationSynaptic dysregulationDegenerative changesBrain slicesCorticostriatal functionPresynaptic terminalsCognitive deficitsNeurodegenerative disordersDiseaseMonths
2008
The Corticostriatal Pathway in Parkinson’s Disease
Bamford N, Cepeda C. The Corticostriatal Pathway in Parkinson’s Disease. Contemporary Neuroscience 2008, 87-104. DOI: 10.1007/978-1-60327-252-0_6.Peer-Reviewed Original ResearchParkinson's diseaseCortico-basal gangliaDopamine-deficient stateStriatal synaptic plasticityCorticostriatal synapseMotor dyskinesiasCorticostriatal pathwayMotor functionStriatal adaptationsAbnormal neurotransmissionSynaptic plasticityThalamocortical loopNeurodegenerative disordersDiseaseDopamine availabilityGangliaMotor movementsGoal-directed behaviorBradykinesiaDyskinesiaNeurotransmissionPathway