Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors
Melief EJ, McKinley JW, Lam JY, Whiteley NM, Gibson AW, Neumaier JF, Henschen CW, Palmiter RD, Bamford NS, Darvas M. Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors. Npj Parkinson's Disease 2018, 4: 23. PMID: 30083593, PMCID: PMC6072777, DOI: 10.1038/s41531-018-0060-6.Peer-Reviewed Original ResearchParkinson's diseaseCentral lateralDopamine neuronsMotor functionDorsal striatumMajor projection fieldBeam-walking testImpairs motor functionViral vector approachLewy body inclusionsMidbrain dopamine neuronsMotor coordination tasksMorris water mazeSlowness of thoughtLoss of glutamateTwo-way active avoidance taskGlutamatergic neuronsMotor abnormalitiesActive avoidance taskLox miceExcitatory inputsThalamic regionsWater mazeCognitive impairmentCell loss