2012
Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans
Hannestad J, Subramanyam K, Dellagioia N, Planeta-Wilson B, Weinzimmer D, Pittman B, Carson RE. Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans. Journal Of Nuclear Medicine 2012, 53: 601-607. PMID: 22414635, PMCID: PMC3717572, DOI: 10.2967/jnumed.111.097014.Peer-Reviewed Original ResearchConceptsNormalized glucose metabolismMontgomery-Åsberg Depression Rating ScalePeak cytokine levelsSystemic inflammationDepression Rating ScaleDepressive symptomsGlucose metabolismCytokine levelsFDG-PETRating ScaleSystemic inflammatory responseCerebral metabolic rateMild depressive symptomsRight anterior cingulateTumor necrosis factorRight anterior insulaSerum levelsInflammatory cytokinesEndotoxin administrationInterleukin-6Inflammatory responseNecrosis factorCingulate subregionsHealthy subjectsInflammation
2010
Citalopram reduces endotoxin-induced fatigue
Hannestad J, DellaGioia N, Ortiz N, Pittman B, Bhagwagar Z. Citalopram reduces endotoxin-induced fatigue. Brain Behavior And Immunity 2010, 25: 256-259. PMID: 20955776, PMCID: PMC3025065, DOI: 10.1016/j.bbi.2010.10.013.Peer-Reviewed Original ResearchConceptsTumor necrosis factorMADRS total scoreDepressive-like symptomsInterleukin-6Serum levelsImmune responseMontgomery-Åsberg Depression Rating ScaleTotal scorePeripheral immune responseLow-dose endotoxinCross-over studyVisual analog scaleDepression Rating ScaleImmune system activationInnate immune responseInnate immune systemEffect sizeTrait Anxiety InventoryModerate effect sizeAnalog scaleInflammatory cytokinesEndotoxin administrationPreventive treatmentNecrosis factorHealthy subjects
2009
A critical review of human endotoxin administration as an experimental paradigm of depression
DellaGioia N, Hannestad J. A critical review of human endotoxin administration as an experimental paradigm of depression. Neuroscience & Biobehavioral Reviews 2009, 34: 130-143. PMID: 19666048, PMCID: PMC2795398, DOI: 10.1016/j.neubiorev.2009.07.014.Peer-Reviewed Original ResearchConceptsImmune system activationEndotoxin administrationSystem activationImmune stimuliDepressive symptomsInnate immune system activationElicit depressive symptomsInterferon-alpha treatmentCommon final pathwayPotential molecular pathwaysImmunologic abnormalitiesImmune depressionVaccine administrationInflammatory cytokinesDepression paradigmDepressed patientsFinal pathwaySymptomsDepression researchAdministrationDepressionMolecular pathwaysBehavioral changesActivationRodents