2024
A group prenatal care intervention reduces gestational weight gain and gestational diabetes in American Samoan women
Hawley N, Faasalele‐Savusa K, Faiai M, Suiaunoa‐Scanlan L, Loia M, Ickovics J, Kocher E, Piel C, Mahoney M, Suss R, Trocha M, Rosen R, Muasau‐Howard B. A group prenatal care intervention reduces gestational weight gain and gestational diabetes in American Samoan women. Obesity 2024, 32: 1833-1843. PMID: 39256170, DOI: 10.1002/oby.24102.Peer-Reviewed Original ResearchConceptsGestational weight gainPostpartum weight changeGestational diabetes screeningClinically important between-group differenceDiabetes screeningGestational diabetesUsual care participantsPrenatal care interventionsMode of birthLow-risk pregnant womenPre-pregnancy obesityAmerican Samoan womenIncidence of gestational diabetesProportion of womenGestational diabetes incidenceInfant birth weightWeight gainBetween-group differencesCare interventionsCare participantsPreliminary effectivenessWeight changeRandom group assignmentDiabetes incidenceHigh-risk settingsAssociations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Rivara A, Russell E, Carlson J, Pomer A, Naseri T, Reupena M, Manna S, Viali S, Minster R, Weeks D, DeLany J, Kershaw E, McGarvey S, Hawley N. Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort. PLOS ONE 2024, 19: e0302643. PMID: 38829901, PMCID: PMC11146712, DOI: 10.1371/journal.pone.0302643.Peer-Reviewed Original ResearchConceptsType 2 diabetesAllele of rs373863828Body mass indexFasting glucoseAdult SamoansDevelopment of type 2 diabetesOdds of type 2 diabetesReduction of modifiable risk factorsRs373863828 genotypeAssociated with higher body mass indexType 2 diabetes developmentGlucose rate of changeMass indexHousehold asset scoreUrbanization of residenceHigher body mass indexRisk factorsModifiable risk factorsRate of changeBaseline variablesMultivariate linear regressionPhysical activityDiabetes preventionType 2 diabetes mellitusSmoking statusThe milk study protocol: A longitudinal, prospective cohort study of the relationship between human milk metabolic hormone concentration, maternal body composition, and early growth and satiety development in Samoan infants aged 1–4 months
Harries V, Abraham J, Vesi L, Reupena A, Faaselele-Savusa K, Duckham R, Bribiescas R, Hawley N. The milk study protocol: A longitudinal, prospective cohort study of the relationship between human milk metabolic hormone concentration, maternal body composition, and early growth and satiety development in Samoan infants aged 1–4 months. PLOS ONE 2024, 19: e0292997. PMID: 38728264, PMCID: PMC11086876, DOI: 10.1371/journal.pone.0292997.Peer-Reviewed Original ResearchConceptsMaternal body compositionEarly infant growthBody compositionInfant growthProspective longitudinal cohortMother-infant dyadsBreastfeeding mother-infant dyadsHuman milkFingerpick blood sampleInfants aged 1Longitudinal cohortBody composition measurementsProspective cohort studyInfant feeding patternsSatiety developmentUndernourished womenSatiety responsivenessInfant satietyInfant hungerHormone leptinCohort studyHigh-income settingsMultivariate analysisEating patternsHormone transfer
2023
Identifying patient preferences for diabetes care: A protocol for implementing a discrete choice experiment in Samoa
Rivara A, Galárraga O, Selu M, Arorae M, Wang R, Faasalele-Savusa K, Rosen R, Hawley N, Viali S. Identifying patient preferences for diabetes care: A protocol for implementing a discrete choice experiment in Samoa. PLOS ONE 2023, 18: e0295845. PMID: 38134044, PMCID: PMC10745180, DOI: 10.1371/journal.pone.0295845.Peer-Reviewed Original Research“There are still broken or fragmented systems”: Qualitative assessment of needs to strengthen adolescent mental health services in American Samoa
Mew E, Blas V, Winschel J, Hunt L, Soliai‐Lemusu S, Johansson A, Lowe S, Faiai M, Naseri J, Toelupe R, Ipou F, Seui M, Ledoux‐Sunia T, Sunia F, Galea’i A, Poulin R, Hawley N, McCutchan‐Tofaeono J. “There are still broken or fragmented systems”: Qualitative assessment of needs to strengthen adolescent mental health services in American Samoa. International Journal Of Mental Health Nursing 2023, 33: 85-92. PMID: 37691318, PMCID: PMC10872981, DOI: 10.1111/inm.13223.Peer-Reviewed Original ResearchConceptsHealth needsAdolescent mental healthMental healthAdolescent mental health servicesCommon mental health problemsMental health servicesAdolescent health needsPost-traumatic stress disorderMental health needsMental health systemMental health problemsAdolescent mental health needsRegion of residenceHealth burdenHigh burdenMental health challengesTreatment accessHealth problemsHealth servicesHealth challengesHealth systemStress disorderAssociation between age at menarche and cardiometabolic risk among Samoan adults
Oyama S, Duckham R, Pomer A, Rivara A, Kershaw E, Wood A, Fidow U, Naseri T, Reupena M, Viali S, McGarvey S, Hawley N. Association between age at menarche and cardiometabolic risk among Samoan adults. American Journal Of Human Biology 2023, 36: e23982. PMID: 37668413, PMCID: PMC10845161, DOI: 10.1002/ajhb.23982.Peer-Reviewed Original ResearchConceptsCardiometabolic riskOne-year increaseSubsequent cardiometabolic riskOdds of hypertensionHigher total cholesterolOdds of diabetesOdds of obesityEarly life exposureFat-free massCardiometabolic morbiditySerum lipidsBlood pressureMedian ageMetabolic syndromeTotal cholesterolProspective studyChildhood adiposityInsulin resistanceObesity prevalenceLife exposureSamoan adultsLean massEarly menarcheLogistic regressionMenarcheProtocol: Implementation and evaluation of an adolescent-mediated intervention to improve glycemic control and diabetes self-management among Samoan adults
Hawley N, Rivara A, Naseri J, Faumuina K, Potoa’e-Solaita N, Iopu F, Faiai M, Naveno E, Tasele S, Lefale T, Lantini R, Carlson J, Rabin T, Semaia P, Mugadza P, Rosen R. Protocol: Implementation and evaluation of an adolescent-mediated intervention to improve glycemic control and diabetes self-management among Samoan adults. PLOS ONE 2023, 18: e0279084. PMID: 36795707, PMCID: PMC9934313, DOI: 10.1371/journal.pone.0279084.Peer-Reviewed Original ResearchConceptsGlycemic controlPrimary efficacy outcomeCardiovascular risk factorsChronic disease riskType 2 diabetesSelf-care strategiesSelf-care practicesHealth behavior changeBehavior changeEfficacy outcomesUsual careDiabetes InterventionsAdult family membersRisk factorsDiabetes knowledgeSamoan adultsIntervention acceptabilityFamily-centered culturePositive behavior changeDisease riskHealth disparitiesActive interventionDisproportionate riskInterventionEthnic minority groups
2022
Validity of anthropometric equation‐based estimators of fat mass in Samoan adults
Heinsberg L, Hawley N, Duckham R, Pomer A, Rivara A, Naseri T, Reupena M, Weeks D, McGarvey S, Minster R. Validity of anthropometric equation‐based estimators of fat mass in Samoan adults. American Journal Of Human Biology 2022, 35: e23838. PMID: 36428275, PMCID: PMC10023273, DOI: 10.1002/ajhb.23838.Peer-Reviewed Original ResearchThe protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans
Hawley NL, Duckham RL, Carlson JC, Naseri T, Reupena MS, Lameko V, Pomer A, Wetzel A, Selu M, Lupematisila V, Unasa F, Vesi L, Fatu T, Unasa S, Faasalele‐Savusa K, Rivara AC, Russell E, Delany JP, Viali S, Kershaw EE, Minster RL, Weeks DE, McGarvey ST. The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity 2022, 30: 2468-2476. PMID: 36284436, PMCID: PMC10111239, DOI: 10.1002/oby.23559.Peer-Reviewed Original ResearchConceptsFat-free massType 2 diabetesFat distributionProtective effectBody compositionFavorable body fat distributionDual-energy X-ray absorptiometry-derived body compositionBody fat distributionGreater fat-free massPercent body fatBody size/compositionAssociation of genotypesRs373863828 genotypeVisceral adiposityHigher BMIAdult SamoansRole of fatGreater BMILean massBody fatLower oddsParadoxical associationTissue-specific mechanismsA alleleDiabetesA stop-gain variant in BTNL9 is associated with atherogenic lipid profiles
Carlson J, Krishnan M, Rosenthal S, Russell E, Zhang J, Hawley N, Moors J, Cheng H, Dalbeth N, de Zoysa J, Watson H, Qasim M, Murphy R, Naseri T, Reupena M, Viali S, Stamp L, Tuitele J, Kershaw E, Deka R, McGarvey S, Merriman T, Weeks D, Minster R. A stop-gain variant in BTNL9 is associated with atherogenic lipid profiles. Human Genetics And Genomics Advances 2022, 4: 100155. PMID: 36340932, PMCID: PMC9630829, DOI: 10.1016/j.xhgg.2022.100155.Peer-Reviewed Original ResearchConceptsStop-gain variantUnique population historyFine-mapping analysisEuropean ancestry populationsGenetic architecturePolynesian populationsPopulation historyGenetic analysisAssociation studiesSuggestive associationPolynesian ancestryCurrent understandingEvidence of associationAmerican SamoaBiological foundationsVariantsGeneticsPopulationNew ZealandBTNL9AncestryPatient preferences for facility-based management of hypertension and diabetes in rural Uganda: a discrete choice experiment
Moor SE, Tusubira AK, Wood D, Akiteng AR, Galusha D, Tessier-Sherman B, Donroe EH, Ngaruiya C, Rabin TL, Hawley NL, Armstrong-Hough M, Nakirya BD, Nugent R, Kalyesubula R, Nalwadda C, Ssinabulya I, Schwartz JI. Patient preferences for facility-based management of hypertension and diabetes in rural Uganda: a discrete choice experiment. BMJ Open 2022, 12: e059949. PMID: 35863829, PMCID: PMC9310153, DOI: 10.1136/bmjopen-2021-059949.Peer-Reviewed Original ResearchConceptsPeer support groupsAvailability of medicinesHealthcare providersPatient preferencesHealth facilitiesHealth educationRural UgandaFacility-based managementCost of treatmentLow-resource settingsDiabetes mellitusNakaseke districtDiscrete choice experimentHealthcare service deliveryAverage respondentIntervention designHTNMedicineUgandan shillingsDCE attributesProvidersGroupService deliveryThe missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans
Fu H, Hawley NL, Carlson JC, Russell EM, Pomer A, Cheng H, Naseri T, Reupena M, Deka R, Choy CC, McGarvey ST, Minster RL, Weeks DE. The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans. Obesity Research & Clinical Practice 2022, 16: 220-227. PMID: 35606300, PMCID: PMC9373717, DOI: 10.1016/j.orcp.2022.04.004.Peer-Reviewed Original ResearchConceptsBMI rateHousehold asset scoreAA genotypeBody mass indexMissense variantsBMI of femalesSex-stratified modelsHigh rateAG participantsBaseline BMIMean BMICohort studyMass indexSamoan adultsPhysical activityGG genotypeBMIAge groupsA alleleLongitudinal changesAsset scoreRs373863828Older participantsFemalesCREBRFCREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
Russell EM, Carlson JC, Krishnan M, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Viali S, Tuitele J, Major TJ, Miljkovic I, Merriman TR, Deka R, Weeks DE, McGarvey ST, Minster RL. CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand. BMJ Open Diabetes Research & Care 2022, 10: e002275. PMID: 35144939, PMCID: PMC8845200, DOI: 10.1136/bmjdrc-2021-002275.Peer-Reviewed Original ResearchConceptsBody mass indexType 2 diabetesAssociation of BMIHigher body mass indexMinor alleleType 2 diabetes riskCross-sectional associationsPacific Island populationsRs373863828 genotypeMass indexDiabetes riskHigher oddsLower oddsDiabetesObesityEvidence of differencesMissense variantsRs373863828Regression analysisGlucoseAssociationOddsIndirect effectsPolynesian individuals
2021
Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease
Katz D, Tahir U, Bick A, Pampana A, Ngo D, Benson M, Yu Z, Robbins J, Chen Z, Cruz D, Deng S, Farrell L, Sinha S, Schmaier A, Shen D, Gao Y, Hall M, Correa A, Tracy R, Durda P, Taylor K, Liu Y, Johnson W, Guo X, Yao J, Ida Chen Y, Manichaikul A, Jain D, Bouchard C, Sarzynski M, Rich S, Rotter J, Wang T, Wilson J, Natarajan P, Gerszten R, Abe N, Abecasis G, Aguet F, Albert C, Almasy L, Alonso A, Ament S, Anderson P, Anugu P, Applebaum-Bowden D, Ardlie K, Arking D, Arnett D, Ashley-Koch A, Aslibekyan S, Assimes T, Auer P, Avramopoulos D, Ayas N, Balasubramanian A, Barnard J, Barnes K, Barr R, Barron-Casella E, Barwick L, Beaty T, Beck G, Becker D, Becker L, Beer R, Beitelshees A, Benjamin E, Benos T, Bezerra M, Bielak L, Bis J, Blackwell T, Blangero J, Boerwinkle E, Bowden D, Bowler R, Brody J, Broeckel U, Broome J, Brown D, Bunting K, Burchard E, Bustamante C, Buth E, Cade B, Cardwell J, Carey V, Carrier J, Carson A, Carty C, Casaburi R, Casas Romero J, Casella J, Castaldi P, Chaffin M, Chang C, Chang Y, Chasman D, Chavan S, Chen B, Chen W, Chen Y, Cho M, Choi S, Chuang L, Chung M, Chung R, Clish C, Comhair S, Conomos M, Cornell E, Correa A, Crandall C, Crapo J, Cupples L, Curran J, Curtis J, Custer B, Damcott C, Darbar D, David S, Davis C, Daya M, de Andrade M, de las Fuentes L, de Vries P, DeBaun M, Deka R, DeMeo D, Devine S, Dinh H, Doddapaneni H, Duan Q, Dugan-Perez S, Duggirala R, Durda J, Dutcher S, Eaton C, Ekunwe L, El Boueiz A, Ellinor P, Emery L, Erzurum S, Farber C, Farek J, Fingerlin T, Flickinger M, Fornage M, Franceschini N, Frazar C, Fu M, Fullerton S, Fulton L, Gabriel S, Gan W, Gao S, Gao Y, Gass M, Geiger H, Gelb B, Geraci M, Germer S, Gerszten R, Ghosh A, Gibbs R, Gignoux C, Gladwin M, Glahn D, Gogarten S, Gong D, Goring H, Graw S, Gray K, Grine D, Gross C, Gu C, Guan Y, Guo X, Gupta N, Haas D, Haessler J, Hall M, Han Y, Hanly P, Harris D, Hawley N, He J, Heavner B, Heckbert S, Hernandez R, Herrington D, Hersh C, Hidalgo B, Hixson J, Hobbs B, Hokanson J, Hong E, Hoth K, Hsiung C, Hu J, Hung Y, Huston H, Hwu C, Irvin M, Jackson R, Jain D, Jaquish C, Johnsen J, Johnson A, Johnson C, Johnston R, Jones K, Kang H, Kaplan R, Kardia S, Kelly S, Kenny E, Kessler M, Khan A, Khan Z, Kim W, Kimoff J, Kinney G, Konkle B, Kooperberg C, Kramer H, Lange C, Lange E, Lange L, Laurie C, Laurie C, LeBoff M, Lee J, Lee S, Lee W, LeFaive J, Levine D, Levy D, Lewis J, Li X, Li Y, Lin H, Lin H, Lin X, Liu S, Liu Y, Liu Y, Loos R, Lubitz S, Lunetta K, Luo J, Magalang U, Mahaney M, Make B, Manichaikul A, Manning A, Manson J, Martin L, Marton M, Mathai S, Mathias R, May S, McArdle P, McDonald M, McFarland S, McGarvey S, McGoldrick D, McHugh C, McNeil B, Mei H, Meigs J, Menon V, Mestroni L, Metcalf G, Meyers D, Mignot E, Mikulla J, Min N, Minear M, Minster R, Mitchell B, Moll M, Momin Z, Montasser M, Montgomery C, Muzny D, Mychaleckyj J, Nadkarni G, Naik R, Naseri T, Natarajan P, Nekhai S, Nelson S, Neltner B, Nessner C, Nickerson D, Nkechinyere O, North K, O’Connell J, O’Connor T, Ochs-Balcom H, Okwuonu G, Pack A, Paik D, Palmer N, Pankow J, Papanicolaou G, Parker C, Peloso G, Peralta J, Perez M, Perry J, Peters U, Peyser P, Phillips L, Pleiness J, Pollin T, Post W, Powers Becker J, Preethi Boorgula M, Preuss M, Psaty B, Qasba P, Qiao D, Qin Z, Rafaels N, Raffield L, Rajendran M, Ramachandran V, Rao D, Rasmussen-Torvik L, Ratan A, Redline S, Reed R, Reeves C, Regan E, Reiner A, Reupena M, Rice K, Rich S, Robillard R, Robine N, Roden D, Roselli C, Rotter J, Ruczinski I, Runnels A, Russell P, Ruuska S, Ryan K, Sabino E, Saleheen D, Salimi S, Salvi S, Salzberg S, Sandow K, Sankaran V, Santibanez J, Schwander K, Schwartz D, Sciurba F, Seidman C, Seidman J, Sériès F, Sheehan V, Sherman S, Shetty A, Shetty A, Sheu W, Shoemaker M, Silver B, Silverman E, Skomro R, Smith A, Smith J, Smith J, Smith N, Smith T, Smoller S, Snively B, Snyder M, Sofer T, Sotoodehnia N, Stilp A, Storm G, Streeten E, Su J, Sung Y, Sylvia J, Szpiro A, Taliun D, Tang H, Taub M, Taylor K, Taylor M, Taylor S, Telen M, Thornton T, Threlkeld M, Tinker L, Tirschwell D, Tishkoff S, Tiwari H, Tong C, Tracy R, Tsai M, Vaidya D, Van Den Berg D, VandeHaar P, Vrieze S, Walker T, Wallace R, Walts A, Wang F, Wang H, Wang J, Watson K, Watt J, Weeks D, Weinstock J, Weir B, Weiss S, Weng L, Wessel J, Willer C, Williams K, Williams L, Wilson C, Wilson J, Winterkorn L, Wong Q, Wu J, Xu H, Yanek L, Yang I, Yu K, Zekavat S, Zhang Y, Zhao S, Zhao W, Zhu X, Zody M, Zoellner S. Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease. Circulation 2021, 145: 357-370. PMID: 34814699, PMCID: PMC9158509, DOI: 10.1161/circulationaha.121.055117.Peer-Reviewed Original ResearchConceptsWhole genome sequence analysisGenome sequence analysisWhole genome sequencing association analysisPlasma proteomeSequence analysisNovel pleiotropic lociNovel genetic determinantsNew protein associationsNew biological mechanismsGenetic architectureNon-European populationsPleiotropic lociGenotyping arraysProtein associationProteomic profilingGene locusGenetic regionsProteomics platformFunctional importanceAssociation analysisProteomeAfrican ancestryGenetic determinantsNovel insightsProteinSocial Support for Self-Care: Patient Strategies for Managing Diabetes and Hypertension in Rural Uganda
Tusubira AK, Nalwadda CK, Akiteng AR, Hsieh E, Ngaruiya C, Rabin TL, Katahoire A, Hawley NL, Kalyesubula R, Ssinabulya I, Schwartz JI, Armstrong-Hough M. Social Support for Self-Care: Patient Strategies for Managing Diabetes and Hypertension in Rural Uganda. Annals Of Global Health 2021, 87: 86. PMID: 34458110, PMCID: PMC8378074, DOI: 10.5334/aogh.3308.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesSelf-care practicesPrescribed medicinesConventional medicinePatient's social support networkRural UgandaSelf-care activitiesBlood sugar levelsCross-sectional qualitative studyResource-limited settingsSelf-care effortsSocial support networksSocial supportNCD clinicsNineteen patientsAdult patientsHealth facilitiesPatientsPatient strategiesManaging diabetesHypertensionSelf-CareDiabetesDiagnostic testsLow-income countriesC‐reactive protein in adult Samoans: Population variation and physiological correlates
Rivara AC, Corley M, Choy CC, Duckham RL, Pomer A, Reupena MS, Viali S, Naseri T, Kershaw EE, Crouter SE, McGarvey ST, Bribiescas RG, Valeggia C, Hawley NL. C‐reactive protein in adult Samoans: Population variation and physiological correlates. American Journal Of Human Biology 2021, 34: e23646. PMID: 34260111, PMCID: PMC8758804, DOI: 10.1002/ajhb.23646.Peer-Reviewed Original ResearchConceptsC-reactive proteinBody mass indexCardiometabolic disease riskMeasures of adiposityAdult SamoansCRP correlateDisease riskSerum C-reactive proteinMeasures of BMICardiometabolic risk markersPercent body fatSex-dependent associationsCardiometabolic markersCardiometabolic riskCRP quartileMass indexUnadjusted analysesRisk markersBody fatKruskal-Wallis testAdiposityPacific Islander populationsSpearman rank correlationFirst examinationRank correlationFeasibility of using infrared thermal imaging to examine brown adipose tissue in infants aged 18 to 25 months
Oyama S, Arslanian KJ, Levy SB, Ocobock CJ, Fidow UT, Naseri T, Hawley NL. Feasibility of using infrared thermal imaging to examine brown adipose tissue in infants aged 18 to 25 months. Annals Of Human Biology 2021, 48: 374-381. PMID: 34781801, DOI: 10.1080/03014460.2021.1985607.Peer-Reviewed Original ResearchBody size and composition of Samoan toddlers aged 18–25 months in 2019
Oyama S, Duckham RL, Arslanian KJ, Kershaw EE, Strayer JA, Fidow UT, Naseri T, Hawley NL. Body size and composition of Samoan toddlers aged 18–25 months in 2019. Annals Of Human Biology 2021, 48: 346-349. PMID: 34340601, PMCID: PMC9912174, DOI: 10.1080/03014460.2021.1951351.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryProspective birth cohortPrimary study aimX-ray absorptiometryGreater linear growthMother-infant dyadsThigh skinfold thicknessRs373863828 genotypeAdult SamoansArm circumferenceAbdominal circumferenceHead circumferenceProtective effectGG genotypeIliac crestLower riskSkinfold thicknessBody compositionBirth cohortStudy aimMinor alleleEarly lifeMissense variantsCircumferenceEarly childhood
2020
Assessing the impact of high blood pressure referrals on hypertension awareness and management, BMI, and blood pressure values in adult Samoans 2010–2019
Rivara AC, Pomer A, Naseri T, Reupena MS, Viali S, Choy CC, McGarvey ST, Hawley NL. Assessing the impact of high blood pressure referrals on hypertension awareness and management, BMI, and blood pressure values in adult Samoans 2010–2019. Annals Of Human Biology 2020, 47: 597-601. PMID: 32924611, PMCID: PMC8180238, DOI: 10.1080/03014460.2020.1822914.Peer-Reviewed Original ResearchConceptsElevated blood pressureBody mass indexBlood pressureNon-communicable diseasesMedication usePhysician diagnosisRisk factorsLong-term health improvementsHypertension medication useBlood pressure valuesNCD risk factorsHypertension controlCardiometabolic healthHypertension awarenessMass indexAdult SamoansHealth referralsDisease burdenReduced oddsBP valuesSamoan adultsReferralLogistic regressionHealth sector actorsMcNemar testA missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
Arslanian KJ, Fidow UT, Atanoa T, Unasa-Apelu F, Naseri T, Wetzel AI, Pomer A, Duckham RL, McGarvey ST, Strayer JA, Kershaw EE, Weeks DE, Hawley NL. A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants. International Journal Of Obesity 2020, 45: 45-55. PMID: 32884101, PMCID: PMC8329753, DOI: 10.1038/s41366-020-00659-4.Peer-Reviewed Original ResearchConceptsBody mass indexDual-energy X-ray absorptiometrySamoan infantsBone massFat massLean massEarly infantsBody compositionInfant body mass indexMinor alleleDeterminants of adiposityOdds of diabetesBone mass accretionMissense variantsX-ray absorptiometryFat-free massCross-sectional analysisMore bone massCREBRF variantProspective studyHigher oddsEarly infancyInfantsAdult populationNatural history