2024
Inducing representational change in the hippocampus through real-time neurofeedback
Peng K, Wammes J, Nguyen A, Iordan C, Norman K, Turk-Browne N. Inducing representational change in the hippocampus through real-time neurofeedback. Philosophical Transactions Of The Royal Society B Biological Sciences 2024, 379: 20230091. PMID: 39428880, PMCID: PMC11491844, DOI: 10.1098/rstb.2023.0091.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingReal-time functional magnetic resonance imagingPatterns of fMRI activityCategorical perception taskReal-time neurofeedbackNeurocognitive mechanismsFMRI sessionStimulus similarityFMRI activationTask demandsBehavioral consequencesUntrained objectsNeural representationPerception taskMemory integrationRepresentational changeEndogenous neuromodulatorNeurofeedbackHippocampusCortical representationIncreased coactivationMagnetic resonance imagingVisual cortexMemoryMultiple theoriesComputational reconstruction of mental representations using human behavior
Caplette L, Turk-Browne N. Computational reconstruction of mental representations using human behavior. Nature Communications 2024, 15: 4183. PMID: 38760341, PMCID: PMC11101448, DOI: 10.1038/s41467-024-48114-6.Peer-Reviewed Original ResearchConceptsMental representationsGoal of cognitive scienceVisual featuresNeural networkMultiple visual conceptsDeep neural networksConceptual representationCognitive scienceVisual conceptsSemantic spaceSemantic featuresHuman behaviorParticipantsNetworkRepresentationStimuliBehaviorFeaturesImagesComputer reconstructionTask
2023
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Sherman B, Harris B, Turk-Browne N, Sinha R, Goldfarb E. Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Journal Of Neuroscience 2023, 43: 7198-7212. PMID: 37813570, PMCID: PMC10601369, DOI: 10.1523/jneurosci.0916-23.2023.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMemory enhancementEpisodic memoryAssociative memoryEpisodic memory encodingBrain regionsHigh-resolution functional magnetic resonance imagingHuman hippocampusHigh-resolution fMRIStress-related hormone cortisolHormone cortisolMemory benefitsEmotional memoryMemory encodingEmotional eventsEmotional associationsHippocampal representationsHippocampal signaturesFunctional neuroimagingHippocampal mechanismsStressful eventsFunctional connectivityHippocampal functionMemory formationSalient information
2022
Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex
Sherman B, Graves K, Huberdeau D, Quraishi I, Damisah E, Turk-Browne N. Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex. Journal Of Neuroscience 2022, 42: 9053-9068. PMID: 36344264, PMCID: PMC9732826, DOI: 10.1523/jneurosci.0708-22.2022.Peer-Reviewed Original ResearchConceptsVisual cortexStatistical learningIntracranial recordingsStatistical learning taskBehavioural Memory TestMultivariate pattern analysisLong-term memoryExpense of memoryEncoding of informationHuman visual cortexStorage of experienceNew experiencesEpisodic memoryMemory researchMemory testFrequency taggingRapid streamGuide behaviorLearning taskNew predictive relationshipNeural predictionHuman intracranial EEGWeak expectationsNeural activityMemory formationRevisiting the Role of the Medial Temporal Lobe in Motor Learning
McDougle SD, Wilterson SA, Turk-Browne NB, Taylor JA. Revisiting the Role of the Medial Temporal Lobe in Motor Learning. Journal Of Cognitive Neuroscience 2022, 34: 532-549. PMID: 34942649, PMCID: PMC8832157, DOI: 10.1162/jocn_a_01809.Peer-Reviewed Original ResearchConceptsMedial temporal lobeMotor learningMemory processesMemory systemTemporal lobeImplicit memory systemDeclarative memory processesMultiple memory systemsAction-outcome associationsMotor learning tasksFlexible action selectionMTL damageDeclarative memoryPsychological mechanismsNeural correlatesSelection deficitsLearning taskAction selectionMotor skillsTaxonomic modelMotor performanceAge-matched controlsAmnesicsPrevious findingsLearningIncreasing stimulus similarity drives nonmonotonic representational change in hippocampus
Wammes J, Norman KA, Turk-Browne N. Increasing stimulus similarity drives nonmonotonic representational change in hippocampus. ELife 2022, 11: e68344. PMID: 34989336, PMCID: PMC8735866, DOI: 10.7554/elife.68344.Peer-Reviewed Original ResearchConceptsRepresentational changeHigh-level visual regionsShaped functionPairs of stimuliHigh-resolution fMRIStimulus similarityVisual regionsHuman participantsHippocampal learningMemoryPlasticity hypothesisCoactivationFMRIHippocampusGyrusStimuliWide enough rangeContradictory resultsParticipantsImage similarityLearningHypothesisU-shapeSimilar imagesEnough range
2021
Retinotopic organization of visual cortex in human infants
Ellis CT, Yates TS, Skalaban LJ, Bejjanki VR, Arcaro MJ, Turk-Browne NB. Retinotopic organization of visual cortex in human infants. Neuron 2021, 109: 2616-2626.e6. PMID: 34228960, DOI: 10.1016/j.neuron.2021.06.004.Peer-Reviewed Original ResearchConceptsVisual cortexFunctional magnetic resonance imagingAdult visual cortexMagnetic resonance imagingVisual areas V1Retinotopic organizationRetinotopic mapResonance imagingHorizontal meridianRetinotopic mappingCortexSubsequent developmental changesArea V1InfantsHuman infantsFunctional maturityFunctional mapsDevelopmental changesLow spatial frequenciesEarly maturationExtrastriateMonthsBehavioral and Neural Fusion of Expectation with Sensation
Panichello MF, Turk-Browne NB. Behavioral and Neural Fusion of Expectation with Sensation. Journal Of Cognitive Neuroscience 2021, 33: 814-825. PMID: 33544058, PMCID: PMC8367740, DOI: 10.1162/jocn_a_01684.Peer-Reviewed Original ResearchConceptsIntegration of expectationsMale-female continuumAuditory association regionsRange of tonesExpectation cuesComputational accountBehavioral judgmentsAssociative learningStimulus identityDifferent cuesFMRI experimentSensory cuesNeural fusionNeural activitySensory informationCuesSpecific predictionsAssociation regionsPerceptionExpectationsConsequence of fusionBehavioralSuch integrationStimuliJudgments
2020
Emergence and organization of adult brain function throughout child development
Yates TS, Ellis CT, Turk-Browne NB. Emergence and organization of adult brain function throughout child development. NeuroImage 2020, 226: 117606. PMID: 33271266, PMCID: PMC8323508, DOI: 10.1016/j.neuroimage.2020.117606.Peer-Reviewed Original ResearchConceptsFMRI activityDevelopmental trajectoriesAdult cognitive neuroscienceInferior frontal gyrusLateral occipital cortexPain-related eventsCognitive neuroscienceFrontal gyrusFunctional neuroanatomyDevelopmental differencesChild developmentAge-related changesCognitive functionDifferent brain regionsSame movieHuman brain developmentNaturalistic approachOccipital cortexBrain regionsAdult brain functionBrain functionChronological ageYoung childrenBrain developmentBrain spaceRe-imagining fMRI for awake behaving infants
Ellis CT, Skalaban LJ, Yates TS, Bejjanki VR, Córdova NI, Turk-Browne NB. Re-imagining fMRI for awake behaving infants. Nature Communications 2020, 11: 4523. PMID: 32908125, PMCID: PMC7481790, DOI: 10.1038/s41467-020-18286-y.Peer-Reviewed Original ResearchConceptsCognitive tasksFunctional magnetic resonance imaging studyTask-evoked activityMagnetic resonance imaging studyCognitive neuroscienceResonance imaging studyFMRI acquisitionHuman infantsFMRI datasetsHuman brainFMRITaskUnique methodological challengesMethodological challengesImaging studiesNeuroscienceInner workingsInfantsMindImportant insightsAcquisitionBrainDecisionsStatistical prediction of the future impairs episodic encoding of the present
Sherman BE, Turk-Browne NB. Statistical prediction of the future impairs episodic encoding of the present. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 22760-22770. PMID: 32859755, PMCID: PMC7502714, DOI: 10.1073/pnas.2013291117.Peer-Reviewed Original ResearchConceptsFunction of memoryEpisodic encodingSource recallEpisodic memoryUpcoming itemsStatistical learningAdaptive purposeFuture experiencesMemoryCurrent itemPast experienceBrain imagingSpecific experiencesBehavioral testsIdiosyncratic propertiesItemsFuture situationsExperienceParticular momentHippocampusRecallEncodingSimilar situationLearningSituationFinding the Pattern: On-Line Extraction of Spatial Structure During Virtual Navigation
Graves KN, Antony JW, Turk-Browne NB. Finding the Pattern: On-Line Extraction of Spatial Structure During Virtual Navigation. Psychological Science 2020, 31: 1183-1190. PMID: 32853531, PMCID: PMC7542246, DOI: 10.1177/0956797620948828.Peer-Reviewed Original ResearchFunctions of ventral visual cortex after bilateral medial temporal lobe damage
Kim JG, Gregory E, Landau B, McCloskey M, Turk-Browne NB, Kastner S. Functions of ventral visual cortex after bilateral medial temporal lobe damage. Progress In Neurobiology 2020, 191: 101819. PMID: 32380224, PMCID: PMC7368375, DOI: 10.1016/j.pneurobio.2020.101819.Peer-Reviewed Original ResearchConceptsMedial temporal lobePerceptual memoryVisual cortexBilateral medial temporal lobe damageMedial temporal lobe damageVentral visual cortexTemporal lobe damageVisual cortex relativeExtensive bilateral lesionsAmnesic patientsLong delayMTL structuresNovel stimuliAdaptation effectsStimuli elicitRapid learningVisual areasMemory systemSingle experienceCortex relativeVisual systemTemporal lobeHippocampal lossStimuliMemoryContent-based Dissociation of Hippocampal Involvement in Prediction
Kok P, Rait LI, Turk-Browne NB. Content-based Dissociation of Hippocampal Involvement in Prediction. Journal Of Cognitive Neuroscience 2020, 32: 527-545. PMID: 31820676, PMCID: PMC6996939, DOI: 10.1162/jocn_a_01509.Peer-Reviewed Original ResearchConceptsPredictive processingAbstract shapesDomain-general processesFemale human participantsComplexity of stimuliComplex visual objectsModality of stimuliTypes of stimuliHigh-resolution fMRIDomain-specific rolesAuditory cuesPartial cuesVisual objectsHippocampal involvementBrain activityHuman participantsDistinct representationsHippocampal responsesComputational roleHippocampal functionPrevious researchStimuliCuesUnexpected orientationSuch accounts
2019
Relating Visual Production and Recognition of Objects in Human Visual Cortex
Fan JE, Wammes JD, Gunn JB, Yamins DLK, Norman KA, Turk-Browne NB. Relating Visual Production and Recognition of Objects in Human Visual Cortex. Journal Of Neuroscience 2019, 40: 1710-1721. PMID: 31871278, PMCID: PMC7046321, DOI: 10.1523/jneurosci.1843-19.2019.Peer-Reviewed Original ResearchConceptsNeural representationVisual cortexRich perceptual informationPotential neural substratesHuman visual cortexRecognition of objectsSimple line drawingsVisual productionPerceptual representationsPerceptual discriminabilityObject cuesPerceptual experienceRecognizable drawingsPerceptual informationNeural substratesNeural mechanismsRepresentational actionsTraining studiesHuman participantsCortex participatesParietal cortexProduction of drawingsEnhanced decodingExperience influencePatterns of connectivityHippocampal-neocortical interactions sharpen over time for predictive actions
Hindy NC, Avery EW, Turk-Browne NB. Hippocampal-neocortical interactions sharpen over time for predictive actions. Nature Communications 2019, 10: 3989. PMID: 31488845, PMCID: PMC6728336, DOI: 10.1038/s41467-019-12016-9.Peer-Reviewed Original ResearchConceptsBackground connectivityAction-outcome associationsVisual cortexHigh-resolution fMRICo-occurring eventsHippocampal predictionsNeural patternsV1/V2Behavioral paradigmsAction informationPrediction changesIndiscriminate bindingGreater differentiationPredictive actionCortexHippocampusFMRIWeak associationReinstatementConnectivityAssociationParadigmOutcomesRetrievalActionComplexity Can Facilitate Visual and Auditory Perception
Ellis CT, Turk-Browne NB. Complexity Can Facilitate Visual and Auditory Perception. Journal Of Experimental Psychology Human Perception & Performance 2019, 45: 1271-1284. PMID: 31318229, PMCID: PMC6706302, DOI: 10.1037/xhp0000670.Peer-Reviewed Original ResearchConceptsPerceptual sensitivityEnhanced long-term memoryLong-term memoryMore distinctive representationsEffects of complexityAuditory perceptionMemory capacityPerceptual changesAuditory inputMemory demandsExperiment 5Experiment 3Experiment 4Experiment 1Experiment 2Informational loadMovie clipsDistinctive representationDrawing attentionImpact perceptionsRich representationSuch sensitivityPerceptionClipsChange detectionNeurofeedback helps to reveal a relationship between context reinstatement and memory retrieval
deBettencourt MT, Turk-Browne NB, Norman KA. Neurofeedback helps to reveal a relationship between context reinstatement and memory retrieval. NeuroImage 2019, 200: 292-301. PMID: 31201985, PMCID: PMC7034791, DOI: 10.1016/j.neuroimage.2019.06.001.Peer-Reviewed Original ResearchConceptsContext reinstatementMental context reinstatementBrain-behavior relationshipsMemory retrievalMultivariate pattern classifierTask-irrelevant imagesRole of neurofeedbackFree recall testList of wordsExpense of memoryMemory positReinstated contextRecall testWorse recallMemory recallMental contextBetter recallNeurofeedbackReinstatementRecallContext imagesWordsSame contextSecond experimentDifferent contextsFocusing on what matters: Modulation of the human hippocampus by relational attention
Córdova NI, Turk‐Browne N, Aly M. Focusing on what matters: Modulation of the human hippocampus by relational attention. Hippocampus 2019, 29: 1025-1037. PMID: 30779473, PMCID: PMC6699927, DOI: 10.1002/hipo.23082.Peer-Reviewed Original ResearchConceptsRelational processingOnline perceptionHippocampal episodic memoryMultivariate pattern analysisLong-term memoryStable hippocampal representationsEpisodic memoryUnivariate activityRelative spatial positionRobust deactivationRelational tasksTemporal tasksTemporal relationsRelational attentionHippocampal representationsItem taskItem processingRelational informationSpatial positionTemporal orderSpatiotemporal contextPattern similarityHuman hippocampusTaskRelational computations
2018
Learning Naturalistic Temporal Structure in the Posterior Medial Network
Aly M, Chen J, Turk-Browne NB, Hasson U. Learning Naturalistic Temporal Structure in the Posterior Medial Network. Journal Of Cognitive Neuroscience 2018, 30: 1345-1365. PMID: 30004848, PMCID: PMC6211568, DOI: 10.1162/jocn_a_01308.Peer-Reviewed Original Research