2024
Environmental, socioeconomic, and health factors associated with gut microbiome species and strains in isolated Honduras villages
Shridhar S, Beghini F, Alexander M, Singh A, Juárez R, Brito I, Christakis N. Environmental, socioeconomic, and health factors associated with gut microbiome species and strains in isolated Honduras villages. Cell Reports 2024, 43: 114442. PMID: 38968070, PMCID: PMC11290354, DOI: 10.1016/j.celrep.2024.114442.Peer-Reviewed Original ResearchGut microbiomeGut microbiome speciesSpecies-level profilingSequenced microbiomesMetagenomic dataMicrobiome speciesHost phenotypeBacterial speciesHuman phenotypesMesoamerican highlandsSeveral speciesGutSpeciesMicrobiomePhenotypeAssociated with body mass indexCommunity-based cohortBody mass indexConsistent with previous findingsSocioeconomic factorsIsolated villagesHousehold wealthMass indexHostStrain
2023
Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide
Diebold P, Rhee M, Shi Q, Trung N, Umrani F, Ahmed S, Kulkarni V, Deshpande P, Alexander M, Thi Hoa N, Christakis N, Iqbal N, Ali S, Mathad J, Brito I. Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide. Nature Communications 2023, 14: 7366. PMID: 37963868, PMCID: PMC10645880, DOI: 10.1038/s41467-023-42998-6.Peer-Reviewed Original ResearchConceptsResistance genesSet of genesGut microbiome samplesHuman gut microbiomeGut microbiotaTaxonomic rangeEnvironmental metagenomesDifferent phylaGut microbiomeTaxonomic associationsIsolate genomesAntibiotic resistance genesAR geneRelevant antibiotic resistance genesGenesDiverse membersHuman metagenomesMicrobiome samplesPCR approachGene profilesAntimicrobial resistance genesCommensal gut microbiotaMobilizable plasmidsMetagenomesImportant pathogen