Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide
Diebold P, Rhee M, Shi Q, Trung N, Umrani F, Ahmed S, Kulkarni V, Deshpande P, Alexander M, Thi Hoa N, Christakis N, Iqbal N, Ali S, Mathad J, Brito I. Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide. Nature Communications 2023, 14: 7366. PMID: 37963868, PMCID: PMC10645880, DOI: 10.1038/s41467-023-42998-6.Peer-Reviewed Original ResearchConceptsResistance genesSet of genesGut microbiome samplesHuman gut microbiomeGut microbiotaTaxonomic rangeEnvironmental metagenomesDifferent phylaGut microbiomeTaxonomic associationsIsolate genomesAntibiotic resistance genesAR geneRelevant antibiotic resistance genesGenesDiverse membersHuman metagenomesMicrobiome samplesPCR approachGene profilesAntimicrobial resistance genesCommensal gut microbiotaMobilizable plasmidsMetagenomesImportant pathogen