2018
Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm
Briggs N, Wei J, Versteeg L, Zhan B, Keegan B, Damania A, Pollet J, Hayes KS, Beaumier C, Seid CA, Leong J, Grencis RK, Bottazzi ME, Sastry KJ, Hotez PJ. Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm. PLOS Pathogens 2018, 14: e1007273. PMID: 30153307, PMCID: PMC6130879, DOI: 10.1371/journal.ppat.1007273.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseImmune correlatesLymph nodesProtective immunityT helper type 2 immune responseT. murisType 2 immune responsesIgE-mediated allergic responsesTh2 cytokines IL-4Adult T. murisAntigen-specific productionCellular immune correlatesHumoral immune correlatesMesenteric lymph nodesInguinal lymph nodesMontanide ISA 720Cytokines IL-4Control of infectionLow drug efficacySubcutaneous vaccineBowel diseaseInfectious causesOral challengeISA 720Protective efficacy
2016
The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections
Briggs N, Weatherhead J, Sastry KJ, Hotez PJ. The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections. PLOS Neglected Tropical Diseases 2016, 10: e0004944. PMID: 27632204, PMCID: PMC5025185, DOI: 10.1371/journal.pntd.0004944.Peer-Reviewed Original Research