Stacking nonenzymatic circuits for high signal gain
Chen X, Briggs N, McLain JR, Ellington AD. Stacking nonenzymatic circuits for high signal gain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 5386-5391. PMID: 23509255, PMCID: PMC3619317, DOI: 10.1073/pnas.1222807110.Peer-Reviewed Original ResearchConceptsSignal amplificationCare molecular diagnosticsSignal amplification schemeMolecular diagnosticsHigh signal gainDynamic DNA hybridizationCircuit leakageDNA circuitsAmplification cascadeDNA hybridizationExponential amplificationProgrammable formAmplification schemeTwo-layer cascadeGreat potentialSignal gainStrand displacementUnique methodProtein enzymes