2024
Luteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation
Barone J, Ho A, Osborne L, Eisenlohr-Moul T, Morrow A, Payne J, Epperson C, Hantsoo L. Luteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation. Psychoneuroendocrinology 2024, 169: 107145. PMID: 39096755, PMCID: PMC11381144, DOI: 10.1016/j.psyneuen.2024.107145.Peer-Reviewed Original ResearchPremenstrual dysphoric disorderSertraline treatmentMultilevel linear modelsDysphoric disorderHypothalamic pituitary gonadalHypothalamic pituitary adrenal (HPA) axisEffects of sertraline treatmentHypothalamic pituitary adrenal (HPA) axis activityPMDD patientsPMDD statusOpen-label sertralineMildly stressful tasksPremenstrual dysphoric disorder groupDaily symptom ratingsSevere affective symptomsEffect of groupPremenstrual symptom severityMenstrual cycle phaseAssociated with higher levelsALLO levelsInflammatory markersMenstrual cycleAffective symptomsAffective disordersClinical interview
2023
GABAergic neuroactive steroid response to sertraline in premenstrual dysphoric disorder
Miller K, Standeven L, Morrow A, Payne J, Epperson C, Hantsoo L. GABAergic neuroactive steroid response to sertraline in premenstrual dysphoric disorder. Psychoneuroendocrinology 2023, 160: 106684. PMID: 38091917, PMCID: PMC10846389, DOI: 10.1016/j.psyneuen.2023.106684.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderSelective serotonin reuptake inhibitorsGABAergic neuroactive steroidsNeuroactive steroid levelsNeuroactive steroidsSertraline treatmentGABA-A receptorsLuteal phasePregnanolone levelsPMDD groupSerum levelsProgesterone ratioDysphoric disorderSteroid levelsSerotonin reuptake inhibitorsPlacebo-controlled designSubsequent luteal phaseEffect of GABAMenstrual cycle phaseNegative mood symptomsGamma-aminobutyric acidPMDD treatmentSSRI treatmentSSRI sertralineReuptake inhibitors