GABAergic neuroactive steroid response to sertraline in premenstrual dysphoric disorder
Miller K, Standeven L, Morrow A, Payne J, Epperson C, Hantsoo L. GABAergic neuroactive steroid response to sertraline in premenstrual dysphoric disorder. Psychoneuroendocrinology 2023, 160: 106684. PMID: 38091917, PMCID: PMC10846389, DOI: 10.1016/j.psyneuen.2023.106684.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderSelective serotonin reuptake inhibitorsGABAergic neuroactive steroidsNeuroactive steroid levelsNeuroactive steroidsSertraline treatmentGABA-A receptorsLuteal phasePregnanolone levelsPMDD groupSerum levelsProgesterone ratioDysphoric disorderSteroid levelsSerotonin reuptake inhibitorsPlacebo-controlled designSubsequent luteal phaseEffect of GABAMenstrual cycle phaseNegative mood symptomsGamma-aminobutyric acidPMDD treatmentSSRI treatmentSSRI sertralineReuptake inhibitors