2000
Electron Capture Dissociation for Structural Characterization of Multiply Charged Protein Cations
Zubarev R, Horn D, Fridriksson E, Kelleher N, Kruger N, Lewis M, Carpenter B, McLafferty F. Electron Capture Dissociation for Structural Characterization of Multiply Charged Protein Cations. Analytical Chemistry 2000, 72: 563-573. PMID: 10695143, DOI: 10.1021/ac990811p.Peer-Reviewed Original ResearchConceptsConventional MS/MS methodsElectron capture dissociationEven-electron ionsIon conversion efficiencyMS/MS methodCapture cross sectionCapture dissociationProtein cationsFragment ionsCAD spectraKinetic energy differenceStructural characterizationElectron captureEV differenceBackbone bondsIon cellsIonic chargeSecondary dissociationPotential wellMS methodCross sectionsIonsElectronsConversion efficiencyEnergy differenceElectron Capture Dissociation Produces Many More Protein Backbone Cleavages Than Collisional and IR Excitation
Zubarev R, Fridriksson E, Horn D, Kelleher N, Kruger N, Lewis M, Carpenter B, Mclafferty F. Electron Capture Dissociation Produces Many More Protein Backbone Cleavages Than Collisional and IR Excitation. 2000, 111-120. DOI: 10.1007/978-1-59259-719-2_7.Peer-Reviewed Original ResearchElectron capture dissociationCapture dissociationProtein backbone cleavageProtein cationsLabile HBackbone cleavageMolecular ionsReduction stepY ionsECD spectraIR excitationCleavage mechanismActivation methodRecombination energyLow-energy electronsInfrared irradiationElectron captureIonsSubsequent cleavageY cleavageConventional activation methodDissociationCleavageSmall proteinsCleavage products
1999
Electron capture dissociation of multiply charged peptide cations11Dedicated to Professor Michael T. Bowers on the occasion of his 60th birthday.
Kruger N, Zubarev R, Horn D, McLafferty F. Electron capture dissociation of multiply charged peptide cations11Dedicated to Professor Michael T. Bowers on the occasion of his 60th birthday. International Journal Of Mass Spectrometry 1999, 185: 787-793. DOI: 10.1016/s1387-3806(98)14215-x.Peer-Reviewed Original ResearchElectron capture dissociationPeptide cationsProfessor Michael T. BowersDissociation of multiplyMichael T. BowersCapture dissociationBond cleavageAmide bondYields productsValuable complementary techniquePossible bondsComplementary techniquesLow-energy electronsCationsBondsDissociationMass valuesPeptidesCleavageEnergy electronsElectronsUnique productsAmino acidsIonsProductsElectron capture versus energetic dissociation of protein ions11Dedicated to the memory of Professor Ben Freiser.
Kruger N, Zubarev R, Carpenter B, Kelleher N, Horn D, McLafferty F. Electron capture versus energetic dissociation of protein ions11Dedicated to the memory of Professor Ben Freiser. International Journal Of Mass Spectrometry 1999, 182: 1-5. DOI: 10.1016/s1387-3806(98)14260-4.Peer-Reviewed Original ResearchElectron Capture Dissociation of Gaseous Multiply-Charged Proteins Is Favored at Disulfide Bonds and Other Sites of High Hydrogen Atom Affinity
Zubarev R, Kruger N, Fridriksson E, Lewis M, Horn D, Carpenter B, McLafferty F. Electron Capture Dissociation of Gaseous Multiply-Charged Proteins Is Favored at Disulfide Bonds and Other Sites of High Hydrogen Atom Affinity. Journal Of The American Chemical Society 1999, 121: 2857-2862. DOI: 10.1021/ja981948k.Peer-Reviewed Original ResearchElectron capture dissociationCapture dissociationLow-energy electronsBackbone bondsLow-energy collisionsHydrogen atom affinityDisulfide bondsElectron captureTandem mass spectrometryGaseous multiplyAtom affinitiesRRKM calculationsNonergodic behaviorMass spectrometerMass spectrometryPeptide chainBondsTrace amountsElectronsTryptophan residuesDissociationSame ringPhotonsExcitationCollisions