2023
Extrauterine epithelioid trophoblastic tumour and its somatic carcinoma mimics: short tandem repeat genotyping meets the diagnostic challenges
Niu N, Ordulu Z, Burak Z, Buza N, Hui P. Extrauterine epithelioid trophoblastic tumour and its somatic carcinoma mimics: short tandem repeat genotyping meets the diagnostic challenges. Histopathology 2023, 84: 325-335. PMID: 37743102, DOI: 10.1111/his.15054.Peer-Reviewed Original ResearchConceptsEpithelioid trophoblastic tumorGestational trophoblastic tumorsTrophoblastic tumorExtrauterine sitesSomatic carcinomasDifferential diagnosisDiagnosis of ETTExtrauterine epithelioid trophoblastic tumorsTriple-negative breast carcinomaTrophoblastic differentiationMetastatic triple-negative breast carcinomaPrimary lung carcinomaMain differential diagnosisMajor differential diagnosisEctopic gestationImmunohistochemical featuresDiagnostic challengeMetastatic tumorsLung carcinomaBreast carcinomaPatient managementEpithelioid malignanciesImmunohistochemical levelCarcinomaTumor tissue
2021
Immunohistochemistry in gynecologic carcinomas: Practical update with diagnostic and clinical considerations based on the 2020 WHO classification of tumors
Buza N. Immunohistochemistry in gynecologic carcinomas: Practical update with diagnostic and clinical considerations based on the 2020 WHO classification of tumors. Seminars In Diagnostic Pathology 2021, 39: 58-77. PMID: 34750021, DOI: 10.1053/j.semdp.2021.10.006.Peer-Reviewed Original ResearchConceptsGynecologic carcinomasOvarian carcinomaPathology evaluationLower genital tract carcinomaMismatch repair protein immunohistochemistryGenital tract carcinomaPD-L1 testingFemale genital tumorsLower genital tractSignificant prognostic differencesPrediction of prognosisRoutine pathology practiceClassification of tumorsMucinous adenocarcinomaPrognostic differencesEndometrial carcinomaHuman papillomavirusGenital tumorsProtein immunohistochemistryWHO classificationPrecursor lesionsGenital tractDiagnostic confirmationDifferential diagnosisImmunohistochemical markersIntraoperative Consultation
Buza N, Euscher E. Intraoperative Consultation. Practical Anatomic Pathology 2021, 317-343. DOI: 10.1007/978-3-030-68608-6_13.Peer-Reviewed Original ResearchFuture fertilityCommon differential diagnostic considerationsIntraoperative frozen section evaluationIntraoperative consultationExtent of surgeryFrozen section evaluationClinical differential diagnosisPatient's future fertilityPreoperative diagnostic workupDifferential diagnostic considerationsFrozen section laboratoryEndometrial cancerOvarian neoplasmsPelvic massCervical carcinomaDiagnostic workupGynecologic pathologyMalignant entitiesDiagnostic challengeSurgical specimensDiagnostic considerationsDifferential diagnosisPathology evaluationSurgical teamDisease type
2017
Comprehensive Analysis of PAX8 Expression in Epithelial Malignancies of the Uterine Cervix
Wong S, Hong W, Hui P, Buza N. Comprehensive Analysis of PAX8 Expression in Epithelial Malignancies of the Uterine Cervix. International Journal Of Gynecological Pathology 2017, 36: 101-106. PMID: 27362905, DOI: 10.1097/pgp.0000000000000309.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaEpithelial malignanciesPAX8 expressionAdenosquamous carcinomaMajority of SCCsCervical squamous cell carcinomaPossible primary sitesEndometrioid-type tumorsWeak nuclear stainingTissue microarray slidesGynecologic malignanciesEndometrial adenocarcinomaEndometrioid adenocarcinomaMetastatic lesionsEndometrial carcinomaMetastatic sitesUterine cervixCell carcinomaCervical tumorsEndocervical adenocarcinomaDifferential diagnosisPrimary siteAdenocarcinomaCarcinomaMalignancy
2010
Gestational trophoblastic disease: histopathological diagnosis in the molecular era
Buza N, Hui P. Gestational trophoblastic disease: histopathological diagnosis in the molecular era. Diagnostic Histopathology 2010, 16: 526-537. DOI: 10.1016/j.mpdhp.2010.08.002.Peer-Reviewed Original ResearchGestational trophoblastic diseaseTrophoblastic diseaseTrophoblastic tumorCharacteristic histological featuresExaggerated placental sitePlacental site noduleEpithelioid trophoblastic tumorTumor-like conditionsFuture diagnostic algorithmsDiagnosis of hydatidiformUnique neoplasmGestational choriocarcinomaPlacental siteHistological featuresHistopathological diagnosisDifferential diagnosisDiagnostic criteriaMolecular testingPlacental trophoblastsProliferative disordersDiagnostic algorithmDiagnosisPartial hydatidiformHeterogeneous groupDiagnostic problems