2012
Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response
Kuerten S, Schickel A, Kerkloh C, Recks MS, Addicks K, Ruddle NH, Lehmann PV. Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response. Acta Neuropathologica 2012, 124: 861-873. PMID: 22842876, DOI: 10.1007/s00401-012-1023-3.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsExperimental autoimmune encephalomyelitisMyelin-specific T cell responseCentral nervous systemB cell aggregatesT cell responsesMultiple sclerosisB cell aggregationDeterminant spreadingB cellsCell responsesActive immune responseMyelin basic proteinLymphoid neogenesisAutoimmune encephalomyelitisMS patientsAggressive diseaseAutoimmune pathologyPatient populationLymphoid organsDisease onsetDisease progressionT cellsImmune responsePathogenic contribution
1993
T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes
Voskuhl R, Martin R, Bergman C, Dalal M, Ruddle N, Mcfarland H. T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes. Autoimmunity 1993, 15: 137-143. PMID: 7692995, DOI: 10.3109/08916939309043888.Peer-Reviewed Original ResearchConceptsExperimental allergic encephalomyelitisMyelin basic proteinMultiple sclerosisT cell linesT cellsMyelin basic protein-specific T lymphocytesMBP-specific T cell linesMurine experimental allergic encephalomyelitisMBP-specific T cellsAntigen-specific cytotoxic activityFunctional phenotypeEncephalitogenic T cellsHuman T cell lineCell linesTh1 subtypeCandidate autoantigenAllergic encephalomyelitisAutoimmune diseasesInflammatory cellsTumor necrosisT lymphocytesInterleukin-4Animal modelsImmunodominant regionCurrent report