2009
Depletion of CD4+CD25+ T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens
Akirav EM, Bergman CM, Hill M, Ruddle NH. Depletion of CD4+CD25+ T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens. Journal Of Neuroscience Research 2009, 87: 3511-3519. PMID: 19125411, PMCID: PMC4429897, DOI: 10.1002/jnr.21981.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAutoantigensAutoimmunityBiomarkersCD4 AntigensCD4-Positive T-LymphocytesCells, CulturedCentral Nervous SystemChemotaxis, LeukocyteDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleInterferon-gammaInterleukin-10Interleukin-17Interleukin-2 Receptor alpha SubunitLymphocyte ActivationMiceMice, Inbred C57BLMultiple SclerosisMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinRatsT-Lymphocytes, RegulatoryConceptsExperimental autoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinAutoimmune encephalomyelitisT cellsIL-10-producing cellsRegulatory T cellsTissue-restricted antigensCentral nervous systemField of autoimmunityT cell activationTreg depletionEAE severitySelf antigensOligodendrocyte glycoproteinForeign antigensExperimental diseaseNervous systemRelated antigensMiceSelf-antigen specificityAntigenTregsEncephalomyelitisAutoimmunityRats
1987
Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones
Mate T, Ruddle N. Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones. International Journal Of Radiation Oncology • Biology • Physics 1987, 13: 61-68. PMID: 2948938, DOI: 10.1016/0360-3016(87)90261-6.Peer-Reviewed Original ResearchConceptsTotal lymphoid irradiationT helper cell clonesSuppressor cellsInterleukin-2Lymphoid irradiationT-helper cell proliferative responsesCell clonesT cell capacityT cell growth factorHelper T cellsT cell populationsCell proliferative responsesMarked inhibitory effectGamma-IFN releaseLympho-reticular tissuesCell growth factorMurine T helper cell clonesNodal irradiationType hypersensitivityAntigen responseImmune suppressionImmunosuppressive effectsLymphokine responsesAntigen presentationT cells
1980
Antigen-specific T-cell hybrids I. Ovalbumin binding T-cell hybrid
Whitaker R, Ruddle N. Antigen-specific T-cell hybrids I. Ovalbumin binding T-cell hybrid. Cellular Immunology 1980, 55: 56-65. PMID: 6159106, DOI: 10.1016/0008-8749(80)90136-7.Peer-Reviewed Original ResearchAntigen-specific molecules from murine T lymphocytes and T cell hybridomas
Goodman J, Lewis G, Primi D, Hornbeck P, Ruddle N. Antigen-specific molecules from murine T lymphocytes and T cell hybridomas. Molecular Immunology 1980, 17: 933-945. PMID: 6163975, DOI: 10.1016/0161-5890(80)90042-5.Peer-Reviewed Original ResearchConceptsJ miceT cellsABA-specific T cellsAntigen-specific suppressor activitySuppressor T cell responseSuppressor T cellsT cell responsesAntigen-specific moleculesLight chain determinantsABA-protein conjugatesT cell moleculesT cell hybridomasIa markersMurine T lymphocytesT lymphocytesRosette formationCell responsesMajor idiotypeSerological analysisCell hybridomasBW 5147Suppressor activityCell lysatesCell moleculesHybridoma cell lines