2011
Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses
Motallebzadeh R, Rehakova S, Conlon TM, Win TS, Callaghan CJ, Goddard M, Bolton EM, Ruddle NH, Bradley JA, Pettigrew GJ. Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses. The FASEB Journal 2011, 26: 51-62. PMID: 21926237, DOI: 10.1096/fj.11-186973.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesBone MarrowCD4-Positive T-LymphocytesChoristomaChronic DiseaseGraft RejectionHeart TransplantationIsoantibodiesLymphoid TissueLymphotoxin beta ReceptorLymphotoxin-betaMiceMice, Inbred C57BLMice, KnockoutMyocardiumNeovascularization, PathologicRecombinant Fusion ProteinsSignal TransductionSpleenTransplantation, HomologousConceptsTertiary lymphoid organsCardiac allograftsHeart allograftsB cellsLymphotoxin β receptor (LTβR) signalingEctopic lymphoid tissueGerminal center activityLTβR-IgTLO formationPostoperative administrationAccelerated rejectionHumoral autoimmunityAlloimmune responseAutoantibody productionAutoantibody responseHumoral responseLymphoid organsLymphoid tissueLymphoid organogenesisEffector antibodiesMouse modelAllograftsTransplantationAutoantibodiesCells
2007
Tertiary Lymphoid Tissues Generate Effector and Memory T Cells That Lead to Allograft Rejection
Nasr IW, Reel M, Oberbarnscheidt MH, Mounzer RH, Baddoura FK, Ruddle NH, Lakkis FG. Tertiary Lymphoid Tissues Generate Effector and Memory T Cells That Lead to Allograft Rejection. American Journal Of Transplantation 2007, 7: 1071-1079. PMID: 17359505, DOI: 10.1111/j.1600-6143.2007.01756.x.Peer-Reviewed Original ResearchConceptsTertiary lymphoid tissueWild-type allograftsMemory T cellsSecondary lymphoid organsLymphoid tissueT cellsLymphoid organsRejection processPrimary alloimmune responsesSyngeneic graft recipientsMemory immune responsesNaïve T cell activationTertiary lymphoid structuresNaive T cellsT cell activationMurine transplantation modelChronic rejectionAllograft rejectionGraft recipientsAlloimmune responseLymphoid structuresChronic inflammationSkin allograftsNaïve lymphocytesTransplantation model
2005
Lymphoid Neogenesis in Murine Cardiac Allografts Undergoing Chronic Rejection
Baddoura FK, Nasr IW, Wrobel B, Li Q, Ruddle NH, Lakkis FG. Lymphoid Neogenesis in Murine Cardiac Allografts Undergoing Chronic Rejection. American Journal Of Transplantation 2005, 5: 510-516. PMID: 15707405, DOI: 10.1111/j.1600-6143.2004.00714.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChronic DiseaseGraft RejectionHeart TransplantationLymphoid TissueMiceMyocardiumTransplantation, HomologousConceptsTertiary lymphoid organsHigh endothelial venulesMurine cardiac allograftsLymphoid neogenesisPeripheral node addressinChronic rejectionCardiac allograftsLymphoid accumulationsLocal T cell activationB cell zonesChronic allograft rejectionT cell activationAcute rejectionAllograft rejectionLymph nodesChronic autoimmunityImmune pathologyLocal antigensLymphoid organsEndothelial venulesNonlymphoid tissuesTransplanted organsAllograftsTarget organsNeogenesis
1977
Role of Endogenous Murine Leukemia Virus in Immunologically Triggered Lymphoreticular Tumors. I. Development and Use of Oncogenic Cellfree Preparations Serially Passaged In Vivo2
Armstrong M, Ruddle N, Lipman M, Pierce S, Richards F. Role of Endogenous Murine Leukemia Virus in Immunologically Triggered Lymphoreticular Tumors. I. Development and Use of Oncogenic Cellfree Preparations Serially Passaged In Vivo2. Journal Of The National Cancer Institute 1977, 58: 67-72. PMID: 13227, DOI: 10.1093/jnci/58.1.67.Peer-Reviewed Original ResearchConceptsLymphoreticular tumorsB-tropic MuLVSyngeneic miceBALB/Reticular tissueMurine leukemia virusYoung adult recipientsLatent periodNormal control miceLeukemia virusEndogenous murine leukemia virusMean latent periodImmunologic disturbancesAdult recipientsControl miceMuLV replicationHost reactionGVHRTumorsMiceB-tropic murine leukemia virusSerial passageCellfree extractsMuLVVirus
1973
TUMOR INDUCTION BY IMMUNOLOGICALLY ACTIVATED MURINE LEUKEMIA VIRUS
Armstrong M, Ruddle N, Lipman M, Richards F. TUMOR INDUCTION BY IMMUNOLOGICALLY ACTIVATED MURINE LEUKEMIA VIRUS. Journal Of Experimental Medicine 1973, 137: 1163-1179. PMID: 4144984, PMCID: PMC2139244, DOI: 10.1084/jem.137.5.1163.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, ViralCell-Free SystemComplement Fixation TestsGraft vs Host ReactionInjections, IntraperitonealLeukemia Virus, MurineLymphomaLymphoma, Large B-Cell, DiffuseMaleMiceMice, Inbred StrainsMicroscopy, ElectronNeoplasm TransplantationNeoplasms, ExperimentalRetroviridaeSpleenTransplantation, HomologousViral Plaque AssayConceptsLymphoreticular tumorsGVHR inductionCF antigenInfectious MuLVInfectious murine leukemia virusMurine leukemia virusNormal control miceTumor-bearing miceSyngeneic recipient miceLeukemia virusMuLV antigensB-tropic MuLVControl miceC-type particlesXC assayRecipient miceSimilar tumorsSpleen cellsSuch miceSyngeneic miceGVHRBALB/Host reactionTumor inductionTumors