2016
The lymphotoxin β receptor is a potential therapeutic target in renal inflammation
Seleznik G, Seeger H, Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwalder M, Segerer S. The lymphotoxin β receptor is a potential therapeutic target in renal inflammation. Kidney International 2016, 89: 113-126. PMID: 26398497, DOI: 10.1038/ki.2015.280.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCell LineChemokinesDisease Models, AnimalEpithelial CellsFemaleGlomerulonephritis, IGAHumansImmunoglobulinsKidney GlomerulusKidney TubulesLigandsLupus NephritisLymphocytesLymphotoxin beta ReceptorLymphotoxin-alphaLymphotoxin-betaMaleMesangial CellsMiceMiddle AgedRNA, MessengerSignal TransductionTranscriptomeConceptsTubular epithelial cellsParietal epithelial cellsEpithelial cellsRenal injuryLTβR signalingTherapeutic targetGlomerular immune complex depositionLymphotoxin β receptor (LTβR) signalingImproved renal functionSerum autoantibody titersHuman tubular epithelial cellsImmune complex depositionMurine lupus modelsProgressive kidney diseaseSuitable therapeutic targetPreclinical mouse modelsDifferent renal compartmentsPotential therapeutic targetΒ Receptor SignalingLymphotoxin β receptorAutoantibody titersRenal inflammationLupus modelsRenal functionRenal biopsy
2011
Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein
Akirav EM, Xu Y, Ruddle NH. Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein. Journal Of Neuroimmunology 2011, 235: 33-39. PMID: 21550671, PMCID: PMC3157307, DOI: 10.1016/j.jneuroim.2011.03.013.Peer-Reviewed Original ResearchConceptsB cellsB cell-deficient μMT miceMyelin oligodendrocyte glycoproteinResident B cellsThymic B cellsCortico-medullary junctionMinor cell populationProduction of LTInsulin mRNA expressionΜMT miceEpithelial cell numberOligodendrocyte glycoproteinThymic expressionAntigen expressionMRNA expressionNormal tissuesCell populationsCell numberCellsExpressionLtUnexpected roleBiological roleLymphotoxinMice
2000
Lymphoid Tissue Homing Chemokines Are Expressed in Chronic Inflammation
Hjelmström P, Fjell J, Nakagawa T, Sacca R, Cuff C, Ruddle N. Lymphoid Tissue Homing Chemokines Are Expressed in Chronic Inflammation. American Journal Of Pathology 2000, 156: 1133-1138. PMID: 10751336, PMCID: PMC1876894, DOI: 10.1016/s0002-9440(10)64981-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDChemokine CCL21Chemokine CXCL13Chemokines, CCChemokines, CXCChronic DiseaseFemaleInflammationLymphotoxin-alphaLymphotoxin-betaMembrane ProteinsMiceMice, Inbred NODMice, TransgenicPancreasPancreatitisProtein IsoformsReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IRNA, MessengerConceptsSecondary lymphoid tissue chemokineB lymphocyte chemoattractantExpression of SLCChronic inflammationLymphoid organsPrediabetic nonobese diabetic (NOD) micePrediabetic NOD miceLymphoid tissue chemokineNonobese diabetic (NOD) miceChronic inflammatory diseaseSecondary lymphoid organsTrafficking of lymphocytesTumor necrosis factor receptor 1Necrosis factor receptor 1Factor receptor 1Homing ChemokinesLymphocyte chemoattractantLymphoid neogenesisNOD miceDendritic cellsDiabetic miceInflammatory diseasesInflammatory processLymphoid tissueInflamed tissues
1993
Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover
Ruddle N, Li C, Horn W, Santiago P, Troiano N, Jay G, Horowitz M, Baron R. Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover. Virology 1993, 197: 196-204. PMID: 8212554, DOI: 10.1006/viro.1993.1580.Peer-Reviewed Original ResearchConceptsHigh bone turnoverHTLV-I infectionBone turnoverMice transgenicSkeletal alterationsAdult T-cell leukemiaMonths of ageSpindle-shaped cellsT-cell leukemiaBone cell activityPaget's diseaseViral etiologyOsteoclast numberBone resorptionPathogenetic mechanismsBone diseaseCell leukemiaBone marrowCell activitySkeletal changesTax mRNASevere skeletal abnormalitiesHost factorsDiseaseSkeletal abnormalities
1992
Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas.
Picarella DE, Kratz A, Li CB, Ruddle NH, Flavell RA. Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 10036-10040. PMID: 1279667, PMCID: PMC50272, DOI: 10.1073/pnas.89.21.10036.Peer-Reviewed Original ResearchConceptsNecrosis factor betaTransgenic miceFactor betaInsulin-dependent diabetes mellitusRat insulin II promoterTumor necrosis factor betaType 1 diabetesRegulation of inflammationTNF-beta geneDiabetes mellitusInflammatory infiltrateInflammatory diseasesT cellsImmune responseB cellsInsulitisDiabetesMicePancreasImportant early stepBetaEarly stagesCD8InfiltratesMellitus