2020
Basics of Inducible Lymphoid Organs
Ruddle NH. Basics of Inducible Lymphoid Organs. Current Topics In Microbiology And Immunology 2020, 426: 1-19. PMID: 32588229, DOI: 10.1007/82_2020_218.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsSecondary lymphoid organsLymphoid tissue organizerHigh endothelial venulesLymphoid organsDendritic cellsB cellsEctopic lymphoid organsFollicular dendritic cellsTertiary lymphoid structuresTertiary lymphoid tissueLymph nodesNK cellsChronic inflammationLTi cellsLymphoid structuresTolerance inductionInducer cellsLymphoid tissueEndothelial venulesAntigen presentationT cellsAccumulation of cellsStromal cellsAutoimmunity
2016
High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation
Ruddle NH. High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation. Frontiers In Immunology 2016, 7: 491. PMID: 27881983, PMCID: PMC5101196, DOI: 10.3389/fimmu.2016.00491.Peer-Reviewed Original ResearchTertiary lymphoid organsHigh endothelial venulesSecondary lymphoid organsLymph nodesAntigen-presenting cellsLymphoid organsEndothelial venulesLymphatic vesselsStromal cellsCentral memory cellsPrimary lymphoid organsTransport antigensGraft rejectionEffector cellsChemokine expressionChronic inflammationPeyer's patchesAntigen presentationInflammatory signalsB cellsBone marrowImmune systemReticular cellsMicrobial infectionsCellular compositionDendritic cells maintain dermal adipose–derived stromal cells in skin fibrosis
Chia JJ, Zhu T, Chyou S, Dasoveanu DC, Carballo C, Tian S, Magro CM, Rodeo S, Spiera RF, Ruddle NH, McGraw TE, Browning JL, Lafyatis R, Gordon JK, Lu TT. Dendritic cells maintain dermal adipose–derived stromal cells in skin fibrosis. Journal Of Clinical Investigation 2016, 126: 4331-4345. PMID: 27721238, PMCID: PMC5096920, DOI: 10.1172/jci85740.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stromal cellsDendritic cellsSkin fibrosisDermal white adipose tissueFibrotic skinAdipose tissueStromal cellsMesenchymal stromal cell therapyScleroderma skin fibrosisStromal cell therapyWhite adipose tissueAdipose-derived stromal cellsMesenchymal stromal cellsΒ expressionMurine modelEffective treatmentFibrosisΒ1-integrin pathwayReparative functionsCell therapySclerodermaSkin functionIntegrin pathwaySurvivalAtrophy
2013
Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles
Mionnet C, Mondor I, Jorquera A, Loosveld M, Maurizio J, Arcangeli ML, Ruddle NH, Nowak J, Aurrand-Lions M, Luche H, Bajénoff M. Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles. PLOS Biology 2013, 11: e1001672. PMID: 24130458, PMCID: PMC3794863, DOI: 10.1371/journal.pbio.1001672.Peer-Reviewed Original ResearchConceptsStromal cell typesB cell folliclesT cell zonesCell typesFate-mapping systemStromal cellsCellular demandB cellsLymph Node Stromal CellsSurvival signalsStromal cell subsetsB cell ablationLN stromal cellsCell zoneAdhesive substrataCell ablationCell subsetsImmune responseCellsFolliclesInflammationSubstrataRegulationTransient boundaryLymphocytes
2003
Helicobacter-Induced Chronic Active Lymphoid Aggregates Have Characteristics of Tertiary Lymphoid Tissue
Shomer NH, Fox JG, Juedes AE, Ruddle NH. Helicobacter-Induced Chronic Active Lymphoid Aggregates Have Characteristics of Tertiary Lymphoid Tissue. Infection And Immunity 2003, 71: 3572-3577. PMID: 12761142, PMCID: PMC155770, DOI: 10.1128/iai.71.6.3572-3577.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigens, SurfaceAutoimmunityCell Adhesion MoleculesCell AggregationChemokine CCL21Chemokine CXCL13Chemokines, CCChemokines, CXCHelicobacter InfectionsHepatitis, ChronicImmunoglobulinsLiverLymphoid TissueMembrane ProteinsMiceMucoproteinsVascular Cell Adhesion Molecule-1ConceptsChronic active hepatitisTertiary lymphoid organsLymphoid organsActive hepatitisInflammatory lesionsHepatic inflammatory lesionsMucosal addressin cell adhesion moleculeTertiary lymphoid tissuePeripheral node addressinLiver cell suspensionsLiver tissue sectionsB220-positive B cellsChemokines SLCHepatic inflammationInflammatory infiltrateChronic autoimmunityLymphoid aggregatesLymphoid tissueFluorescence-activated cell sortingT cellsCell adhesion moleculeB cellsStromal cellsSmall venulesAdhesion molecules