2020
Basics of Inducible Lymphoid Organs
Ruddle NH. Basics of Inducible Lymphoid Organs. Current Topics In Microbiology And Immunology 2020, 426: 1-19. PMID: 32588229, DOI: 10.1007/82_2020_218.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsSecondary lymphoid organsLymphoid tissue organizerHigh endothelial venulesLymphoid organsDendritic cellsB cellsEctopic lymphoid organsFollicular dendritic cellsTertiary lymphoid structuresTertiary lymphoid tissueLymph nodesNK cellsChronic inflammationLTi cellsLymphoid structuresTolerance inductionInducer cellsLymphoid tissueEndothelial venulesAntigen presentationT cellsAccumulation of cellsStromal cellsAutoimmunity
2012
Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma
Stranford S, Ruddle NH. Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma. Frontiers In Immunology 2012, 3: 350. PMID: 23230435, PMCID: PMC3515885, DOI: 10.3389/fimmu.2012.00350.Peer-Reviewed Original ResearchSecondary lymphoid organsFollicular dendritic cellsHigh endothelial venulesLymph nodesDendritic cellsChronic inflammationLymphoid organsLymphoid tissueEndothelial venulesTertiary lymphoid organsAnti-tumor responseEctopic lymphoid tissueLymph node stromaTertiary lymphoid tissueNon-lymphoid organsLymphatic vesselsAutoimmune activityGraft rejectionAutoimmune responseInflammatory signalsTransgenic miceTherapeutic interventionsReticular cellsStromal componentsVivo real time
1997
Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice
Koni P, Sacca R, Lawton P, Browning J, Ruddle N, Flavell R. Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice. Immunity 1997, 6: 491-500. PMID: 9133428, DOI: 10.1016/s1074-7613(00)80292-7.Peer-Reviewed Original ResearchConceptsMesenteric lymph nodesLT alpha-deficient miceAlpha-deficient miceFollicular dendritic cellsBeta-deficient miceLymph nodesDendritic cellsDeficient miceLymphoid organogenesisTumor necrosis factor receptor type ILTbeta-deficient micePeripheral lymph nodesReceptor type ISplenic germinal centersLymphotoxin βPeyer's patchesGerminal centersLymphotoxin alphaLT-alphaLT alpha3Lymphotoxin αMiceUnidentified receptorType IAlpha