2013
The development of tertiary lymphoid organs in the central nervous system facilitates determinant spreading of the MP4-specific T cell response (P4164)
Kuerten S, Schickel A, Kerkloh C, Recks M, Addicks K, Ruddle N, Lehmann P. The development of tertiary lymphoid organs in the central nervous system facilitates determinant spreading of the MP4-specific T cell response (P4164). The Journal Of Immunology 2013, 190: 172.9-172.9. DOI: 10.4049/jimmunol.190.supp.172.9.Peer-Reviewed Original ResearchTertiary lymphoid organsT cell responsesCentral nervous systemExperimental autoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinMultiple sclerosisCell responsesLymphoid organsNervous systemFormation of TLOsAntigen-specific T cell responsesSecondary progressive multiple sclerosisHuman autoimmune disease multiple sclerosisAutoimmune disease multiple sclerosisT cell compartmentalizationB cell aggregatesChronic disease stageDisease multiple sclerosisSevere clinical diseaseHigh endothelial venulesGerminal center formationMyelin basic proteinAutoimmune encephalomyelitisCNS autoimmunityCortical pathology
2012
Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response
Kuerten S, Schickel A, Kerkloh C, Recks MS, Addicks K, Ruddle NH, Lehmann PV. Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response. Acta Neuropathologica 2012, 124: 861-873. PMID: 22842876, DOI: 10.1007/s00401-012-1023-3.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsExperimental autoimmune encephalomyelitisMyelin-specific T cell responseCentral nervous systemB cell aggregatesT cell responsesMultiple sclerosisB cell aggregationDeterminant spreadingB cellsCell responsesActive immune responseMyelin basic proteinLymphoid neogenesisAutoimmune encephalomyelitisMS patientsAggressive diseaseAutoimmune pathologyPatient populationLymphoid organsDisease onsetDisease progressionT cellsImmune responsePathogenic contribution