2012
Fluorescent transgenic reporter mice can be used for in vivo Imaging of lymphatic vessels and high endothelial venules in a Sjögren’s model (61.7)
Ruddle N, Truman L, Bentley K, Alonso-Gonzalez N. Fluorescent transgenic reporter mice can be used for in vivo Imaging of lymphatic vessels and high endothelial venules in a Sjögren’s model (61.7). The Journal Of Immunology 2012, 188: 61.7-61.7. DOI: 10.4049/jimmunol.188.supp.61.7.Peer-Reviewed Original ResearchTertiary lymphoid organsLymphocyte infiltrationSjögren's syndromeLymphatic vesselsReporter miceTransgenic miceB cell compartmentalizationSalivary glandsExtra-nodal lymphomaHigh endothelial venulesMinor salivary glandsEGFP reporter miceTransgenic reporter miceAntigen primingSjögren's patientsVascular changesAutoantibody productionBL/6 miceAutoimmune diseasesLymphoid organsSpontaneous lymphomasEndothelial venulesGerminal centersLymph flowImmature phenotype
2011
Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses
Motallebzadeh R, Rehakova S, Conlon TM, Win TS, Callaghan CJ, Goddard M, Bolton EM, Ruddle NH, Bradley JA, Pettigrew GJ. Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses. The FASEB Journal 2011, 26: 51-62. PMID: 21926237, DOI: 10.1096/fj.11-186973.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesBone MarrowCD4-Positive T-LymphocytesChoristomaChronic DiseaseGraft RejectionHeart TransplantationIsoantibodiesLymphoid TissueLymphotoxin beta ReceptorLymphotoxin-betaMiceMice, Inbred C57BLMice, KnockoutMyocardiumNeovascularization, PathologicRecombinant Fusion ProteinsSignal TransductionSpleenTransplantation, HomologousConceptsTertiary lymphoid organsCardiac allograftsHeart allograftsB cellsLymphotoxin β receptor (LTβR) signalingEctopic lymphoid tissueGerminal center activityLTβR-IgTLO formationPostoperative administrationAccelerated rejectionHumoral autoimmunityAlloimmune responseAutoantibody productionAutoantibody responseHumoral responseLymphoid organsLymphoid tissueLymphoid organogenesisEffector antibodiesMouse modelAllograftsTransplantationAutoantibodiesCells