2011
Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses
Motallebzadeh R, Rehakova S, Conlon TM, Win TS, Callaghan CJ, Goddard M, Bolton EM, Ruddle NH, Bradley JA, Pettigrew GJ. Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses. The FASEB Journal 2011, 26: 51-62. PMID: 21926237, DOI: 10.1096/fj.11-186973.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesBone MarrowCD4-Positive T-LymphocytesChoristomaChronic DiseaseGraft RejectionHeart TransplantationIsoantibodiesLymphoid TissueLymphotoxin beta ReceptorLymphotoxin-betaMiceMice, Inbred C57BLMice, KnockoutMyocardiumNeovascularization, PathologicRecombinant Fusion ProteinsSignal TransductionSpleenTransplantation, HomologousConceptsTertiary lymphoid organsCardiac allograftsHeart allograftsB cellsLymphotoxin β receptor (LTβR) signalingEctopic lymphoid tissueGerminal center activityLTβR-IgTLO formationPostoperative administrationAccelerated rejectionHumoral autoimmunityAlloimmune responseAutoantibody productionAutoantibody responseHumoral responseLymphoid organsLymphoid tissueLymphoid organogenesisEffector antibodiesMouse modelAllograftsTransplantationAutoantibodiesCells
2007
Tertiary Lymphoid Tissues Generate Effector and Memory T Cells That Lead to Allograft Rejection
Nasr IW, Reel M, Oberbarnscheidt MH, Mounzer RH, Baddoura FK, Ruddle NH, Lakkis FG. Tertiary Lymphoid Tissues Generate Effector and Memory T Cells That Lead to Allograft Rejection. American Journal Of Transplantation 2007, 7: 1071-1079. PMID: 17359505, DOI: 10.1111/j.1600-6143.2007.01756.x.Peer-Reviewed Original ResearchConceptsTertiary lymphoid tissueWild-type allograftsMemory T cellsSecondary lymphoid organsLymphoid tissueT cellsLymphoid organsRejection processPrimary alloimmune responsesSyngeneic graft recipientsMemory immune responsesNaïve T cell activationTertiary lymphoid structuresNaive T cellsT cell activationMurine transplantation modelChronic rejectionAllograft rejectionGraft recipientsAlloimmune responseLymphoid structuresChronic inflammationSkin allograftsNaïve lymphocytesTransplantation model