2001
ICOS co-stimulatory receptor is essential for T-cell activation and function
Dong C, Juedes A, Temann U, Shresta S, Allison J, Ruddle N, Flavell R. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 2001, 409: 97-101. PMID: 11343121, DOI: 10.1038/35051100.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody FormationAntigens, CDAntigens, Differentiation, T-LymphocyteCell DifferentiationCells, CulturedEncephalomyelitis, Autoimmune, ExperimentalGene TargetingHemocyaninsInducible T-Cell Co-Stimulator ProteinInterleukin-13Interleukin-4Lymph NodesLymphocyte ActivationMiceMice, KnockoutMolecular Sequence DataMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinT-LymphocytesConceptsInducible co-stimulatory moleculeT cell activationCo-stimulatory moleculesT cellsICOS-/- miceICOS-deficient miceInflammatory autoimmune diseaseExperimental autoimmune encephalomyelitisInjection of lipopolysaccharideCo-stimulatory receptorsHumoral immune responseNon-immune tissuesT lymphocyte activationAutoimmune encephalomyelitisAutoimmune diseasesImmune responseInterleukin-4Immune functionCD28/CTLA4 familyB cellsProtective roleEnhanced susceptibilityActivationReceptorsHigh affinity
1994
10 Studies of Tolerance, Inflammation, and Autoimmunity in Transgenic Mice
Antonia S, Elliott E, Guerder S, Picarella D, Ruddle N, Flavell R. 10 Studies of Tolerance, Inflammation, and Autoimmunity in Transgenic Mice. 1994, 155-174. DOI: 10.1016/b978-0-12-105760-2.50014-5.Peer-Reviewed Original ResearchAutoreactive T cellsT cellsTransgenic miceT antigen transgenic miceLocal antigen presentationSpecific T cellsInfluence of cytokinesAutoreactive cellsAntigen presentationTissue destructionEffective antigenAutoimmunityClonal expansionMiceTissue remodelingStudy of toleranceAntigenIsletsCellsTissueActivationInflammationHyperplasiaCytokinesExpression