2007
Urinary Free Cortisol: An Intermediate Phenotype and a Potential Genetic Marker for a Salt-Resistant Subset of Essential Hypertension
Chamarthi B, Kolatkar NS, Hunt SC, Williams JS, Seely EW, Brown NJ, Murphey LJ, Jeunemaitre X, Williams GH. Urinary Free Cortisol: An Intermediate Phenotype and a Potential Genetic Marker for a Salt-Resistant Subset of Essential Hypertension. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 1340-1346. PMID: 17264181, DOI: 10.1210/jc.2006-2093.Peer-Reviewed Original ResearchConceptsUrinary free cortisolEssential hypertensionHigh urinary free cortisolLow-salt dietMean arterial pressureIntermediate phenotypesStrong familial componentArterial pressureDietary sodiumBlood pressureFree cortisolHypertensive siblingsHypertensionHypertensivesNormotensivesGeneral communityHypertensive familiesFamilial componentPreliminary reportFamilial aggregationSignificant predictorsPotential genetic markersSignificant differencesSignificant proportionCortisol
1999
Clinical Experience Over 48 Years With Pheochromocytoma
Goldstein R, O’Neill J, Holcomb G, Morgan W, Neblett W, Oates J, Brown N, Nadeau J, Smith B, Page D, Abumrad N, Scott H. Clinical Experience Over 48 Years With Pheochromocytoma. Annals Of Surgery 1999, 229: 755. PMID: 10363888, PMCID: PMC1420821, DOI: 10.1097/00000658-199906000-00001.Peer-Reviewed Original ResearchConceptsMicroscopic malignant featuresExtraadrenal pheochromocytomaMalignant diseaseMalignant featuresAdrenal pheochromocytomaSurgical managementMultiple endocrine neoplasia type 2Von Hippel-Lindau diseasePatient's malignant diseaseSame overall survivalLong-term outcomesRate of malignancyKaplan-Meier survival distributionsNumber of patientsVon Recklinghausen's diseaseHippel-Lindau diseaseAreas of controversyCarney syndromeAdrenal tumorsOverall survivalMale patientsFemale patientsBenign diseasePatient survivalFormer tumor