2020
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.
Lopez MG, Hughes CG, DeMatteo A, O’Neal J, McNeil JB, Shotwell MS, Morse J, Petracek MR, Shah AS, Brown NJ, Billings FT. Intraoperative Oxidative Damage and Delirium after Cardiac Surgery. Anesthesiology 2020, 132: 551-561. PMID: 31770146, PMCID: PMC7015795, DOI: 10.1097/aln.0000000000003016.Peer-Reviewed Original ResearchConceptsS100 calcium-binding protein BCalcium-binding protein BUbiquitin carboxyl-terminal hydrolase isozyme L1Blood-brain barrier disruptionNeuronal injuryPostoperative deliriumF2-isoprostanesBarrier disruptionOxidative damageConfusion Assessment MethodCardiac surgery patientsPostoperative day 1Intensive care unitBlood-brain barrierEnzyme-linked immunosorbentProtein BKidney injuryCohort studySurgery patientsCardiac surgeryTotal cohortCare unitIndependent associationClinical trialsPlasma concentrations
2004
Angiotensin‐converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass
Pretorius M, McFarlane JA, Vaughan DE, Brown NJ, Murphey LJ. Angiotensin‐converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass. Clinical Pharmacology & Therapeutics 2004, 76: 379-387. PMID: 15470338, DOI: 10.1016/j.clpt.2004.06.004.Peer-Reviewed Original ResearchConceptsACE inhibitor groupMinutes of CPBCardiopulmonary bypassACE inhibitorsInhibitor groupKinin responseBradykinin concentrationsEffects of CPBCoronary artery bypass surgeryTissue-type plasminogen activator antigenPreoperative ACE inhibitorsArtery bypass surgeryPostoperative day 1Concentrations of bradykininEffect of smokingPlasminogen activator antigenKallikrein-kinin systemSignificant inverse correlationArterial pressureBypass surgeryFibrinolytic responseVenous bloodACE activityDay 1Enzyme inhibitors
2003
Angiotensin-Converting Enzyme Inhibition Alters the Fibrinolytic Response to Cardiopulmonary Bypass
Pretorius M, Murphey LJ, McFarlane JA, Vaughan DE, Brown NJ. Angiotensin-Converting Enzyme Inhibition Alters the Fibrinolytic Response to Cardiopulmonary Bypass. Circulation 2003, 108: 3079-3083. PMID: 14656921, DOI: 10.1161/01.cir.0000105765.54573.60.Peer-Reviewed Original ResearchConceptsPostoperative day 1PAI-1 antigenCardiopulmonary bypassACE inhibitorsPAI-1 expressionACEI groupACE inhibitionPlasminogen activator inhibitor-1 (PAI-1) concentrationsTPA activityTissue-type plasminogen activator antigenAngiotensin-converting enzyme inhibitionAcute graft thrombosisPreoperative ACE inhibitorsMorning of surgeryCoronary artery bypassVein graft occlusionPlasminogen activator antigenArterial blood samplesArtery bypassGraft thrombosisGraft occlusionFibrinolytic responseAngiotensin IIBlood samplesDay 1