2009
Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Artery Bypass Graft Surgery
Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry T, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman; D, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D. Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Artery Bypass Graft Surgery. Circulation Genomic And Precision Medicine 2009, 2: 499-506. PMID: 20031626, PMCID: PMC2801871, DOI: 10.1161/circgenetics.109.849075.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryPostoperative atrial fibrillationBypass graft surgeryGraft surgeryAtrial fibrillationSingle nucleotide polymorphismsValidation cohortDiscovery cohortCardiac surgery cohortConcurrent valve surgeryCommon adverse eventsCohort of patientsAdditive odds ratioMultiple comparisonsChromosome 4q25 variantsSurgery cohortValve surgeryAdverse eventsClinical predictorsAmbulatory populationOdds ratioClinical covariatesUS CentersMultivariate predictors
2007
Ala92 Type 2 Deiodinase Allele Increases Risk for the Development of Hypertension
Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. Ala92 Type 2 Deiodinase Allele Increases Risk for the Development of Hypertension. Hypertension 2007, 49: 461-466. PMID: 17224473, DOI: 10.1161/01.hyp.0000256295.72185.fd.Peer-Reviewed Original ResearchConceptsDevelopment of hypertensionType 2 iodothyronine deiodinaseNormotensive subjectsIodothyronine deiodinaseConversion of thyroxineSequenom MassARRAY platformEuthyroid adultsThr92Ala polymorphismEuthyroid subjectsOdds ratioHypertensionPeripheral tissuesAllele carriersIncrease riskMassARRAY platformInfluence susceptibilityHypertension susceptibilityThyroid pathwaysIntermediate phenotypesPresent studyNonsynonymous polymorphismsSubjectsDeiodinaseRiskAllele frequencies
2005
Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension
King LM, Gainer JV, David GL, Dai D, Goldstein JA, Brown NJ, Zeldin DC. Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. Pharmacogenetics And Genomics 2005, 15: 7-13. PMID: 15864120, DOI: 10.1097/01213011-200501000-00002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesArginineAryl Hydrocarbon HydroxylasesCytochrome P-450 CYP2C8Cytochrome P-450 CYP2J2Cytochrome P-450 Enzyme SystemElectrolytesFemaleGenotypeHumansHypertensionLinkage DisequilibriumLysineMaleMiddle AgedOdds RatioOxygenasesPharmacogeneticsPolymorphism, GeneticPolymorphism, Single NucleotideRiskSex FactorsConceptsFamily historyVariant allele frequencyCaucasian maleGenotype distributionVariant allelesArachidonic acidRisk of hypertensionBody mass indexAdditional subgroup analysesAfrican AmericansCis-epoxyeicosatrienoic acidsBiethnic populationNormotensive CaucasiansHypertensive subjectsAllele frequenciesMass indexVascular toneHypertension riskHypertension statusSubgroup analysisOdds ratioHypertensionProtective effectCYP2C8 geneCYP2J2