2013
Asn441 plays a key role in folding and function of the Na+/I– symporter (NIS)
Li W, Nicola JP, Amzel LM, Carrasco N. Asn441 plays a key role in folding and function of the Na+/I– symporter (NIS). The FASEB Journal 2013, 27: 3229-3238. PMID: 23650190, PMCID: PMC3714583, DOI: 10.1096/fj.13-229138.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsAsparagineBinding SitesBiological TransportCell LineCell MembraneChlorocebus aethiopsCOS CellsHumansImmunoblottingIodineMicroscopy, ConfocalModels, MolecularMolecular Sequence DataMutationProtein FoldingProtein Structure, SecondaryProtein Structure, TertiarySequence Homology, Amino AcidSymportersTransport Vesicles
2007
The Na+/I− symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate
Dohán O, Portulano C, Basquin C, Reyna-Neyra A, Amzel LM, Carrasco N. The Na+/I− symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20250-20255. PMID: 18077370, PMCID: PMC2154417, DOI: 10.1073/pnas.0707207104.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportCell LineDogsEnvironmental PollutantsIodineKineticsMilkModels, TheoreticalPerchloratesRatsSymportersTransfectionConceptsI- uptakeExposure of newbornsDifferent stoichiometriesIodine-containing thyroid hormonesPublic health impactStoichiometryMaternal milkLactating breastPerchlorateGreater health risksThyroid hormonesEnvironmental pollutant perchlorateDifferent substratesCNS developmentSuch exposureU.S. populationProper CNS developmentCompetitive inhibitorHealth impactsNewbornsKey plasma membrane proteinThyroidBreastHealth risksAnions