Breast cancer stem cells: A review of their characteristics and the agents that affect them
Shan N, Shin Y, Yang G, Furmanski P, Suh N. Breast cancer stem cells: A review of their characteristics and the agents that affect them. Molecular Carcinogenesis 2021, 60: 73-100. PMID: 33428807, PMCID: PMC7855917, DOI: 10.1002/mc.23277.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBreast cancer stem cellsCancer stem cellsBreast cancerCell surface markersCombination therapyTherapeutic effectNew tumorsEffective treatmentXenografted miceCancer developmentSurface markersSerial transplantationCancerPotential agentFurther studiesTranscription factorsTumorsStem cellsBiological effectsKPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells
Cordover E, Wei J, Patel C, Shan N, Gionco J, Sargsyan D, Wu R, Cai L, Kong A, Jacinto E, Minden A. KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells. Chemical Research In Toxicology 2019, 33: 482-491. PMID: 31876149, PMCID: PMC9316853, DOI: 10.1021/acs.chemrestox.9b00376.Peer-Reviewed Original ResearchConceptsCell growthSerine/threonine kinase mTORNicotinamide phosphoribosyltransferaseBreast cancer cellsTNBC cellsRegulation of RictorPak4 protein kinaseCancer cellsInhibition of PAK4Triple-negative breast cancerTriple-negative breast cancer cellsMTORC2 signalingKinase mTORProtein kinaseRNA sequencingTNBC cell growthNegative breast cancer cellsCell metabolismRictorPAK4Overexpressing cellsSpecific inhibitorDruggable targetsMTOR pathwayInhibits growth