2020
Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study
Hillmer AT, Matuskey D, Huang Y, Nabulsi N, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP. Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study. Journal Of Nuclear Medicine 2020, 61: 1200-1204. PMID: 32005773, PMCID: PMC7413239, DOI: 10.2967/jnumed.119.237735.Peer-Reviewed Original ResearchConceptsTobacco smokingTobacco smokersTSPO levelsImmune systemPET studiesBrain immune systemBrain TSPO levelsPrimary immunocompetent cellsPrevious PET studiesTranslocator proteinTranslocator protein (TSPO) levelsInflammatory effectsImmunocompetent cellsArterial bloodTobacco smokePET scansNonsmokersSmokersRadiotracer concentrationMedium effect sizeSmokingPET imagingBrainProtein levelsSignificant differences
2019
Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release
Wai JM, Grassetti A, Slifstein M, Matuskey D, Nabulsi N, Ropchan J, Labaree D, Huang Y, Martinez D. Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release. Drug And Alcohol Dependence 2019, 205: 107627. PMID: 31669800, PMCID: PMC6893096, DOI: 10.1016/j.drugalcdep.2019.107627.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPositron emission tomographyDopamine releaseBinge drinkersHealthy controlsBinge drinkingReceptor bindingUse disordersStriatal dopamine receptor bindingYoung adult binge drinkersAdult binge drinkersAlcohol Use Disorders Identification Test (AUDIT) scoresDopamine receptor bindingFuture alcohol use disordersSubstance use disordersSignificant differencesPrevious imaging studiesOral methylphenidateRisk factorsDopamine transmissionHC subjectsAlcoholism criteriaAlcohol abuseDrinking historySignificant association