2020
PET imaging of mGluR5 in Alzheimer’s disease
Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer’s disease. Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.Peer-Reviewed Original ResearchConceptsEarly Alzheimer's diseaseAlzheimer's diseaseMild cognitive impairmentBrain amyloidHippocampus of ADPositron emission tomography radioligandSubtype 5 receptorsMild AD dementiaGray matter atrophyAssociation cortical regionsAmnestic mild cognitive impairmentImportant therapeutic targetCerebellum reference regionDynamic PET scansHippocampal mGluR5MethodsSixteen individualsMGluR5 bindingSynaptotoxic actionAD dementiaAD pathogenesisMatter atrophyInitial administrationAD groupSynaptic transmissionEntorhinal cortex
2013
Imaging Glutamate Homeostasis in Cocaine Addiction with the Metabotropic Glutamate Receptor 5 Positron Emission Tomography Radiotracer [11C]ABP688 and Magnetic Resonance Spectroscopy
Martinez D, Slifstein M, Nabulsi N, Grassetti A, Urban NB, Perez A, Liu F, Lin SF, Ropchan J, Mao X, Kegeles LS, Shungu DC, Carson RE, Huang Y. Imaging Glutamate Homeostasis in Cocaine Addiction with the Metabotropic Glutamate Receptor 5 Positron Emission Tomography Radiotracer [11C]ABP688 and Magnetic Resonance Spectroscopy. Biological Psychiatry 2013, 75: 165-171. PMID: 24035345, PMCID: PMC4106018, DOI: 10.1016/j.biopsych.2013.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCarbon RadioisotopesCase-Control StudiesChoice BehaviorCocaineCocaine-Related DisordersCorpus StriatumFunctional NeuroimagingGlutamic AcidGlutamineHomeostasisHumansMagnetic Resonance SpectroscopyMaleOximesPositron-Emission TomographyPyridinesReceptor, Metabotropic Glutamate 5Self AdministrationYoung AdultConceptsHealthy control subjectsCocaine addictionControl subjectsLong-term cocaine useMagnetic resonance spectroscopy measuresGlutamate-glutamine levelsMGluR5 receptor bindingCocaine self-administration sessionsPositron emission tomography (PET) radiotracerPositron emission tomographySelf-administration sessionsCocaine-seeking behaviorSelf-administer cocaineMGluR5 bindingMGluR5 availabilityLeft striatumCocaine exposurePreclinical studiesGlutamate homeostasisGlutamate turnoverSubcortical regionsStriatumCocaine useMagnetic resonance spectroscopySecondary analysis