2019
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study
Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y. Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study. Neuropsychopharmacology 2019, 44: 1720-1727. PMID: 31026862, PMCID: PMC6785004, DOI: 10.1038/s41386-019-0398-4.Peer-Reviewed Original ResearchConceptsCocaine use disorderStress-induced relapsePositron emission tomographyCocaine bingeKappa-opioid receptor/dynorphin systemKOR selective agonistPositron emission tomography studyKappa-opioid receptorsCold pressor testCocaine self-administration sessionsEmission tomography studiesSelf-administration sessionsStress-induced cocaineEndogenous dynorphinDynorphin systemHealthy controlsPressor testSelective agonistPET scansAnimal studiesKOR bindingReceptor availabilitySignificant associationBrain regionsEmission tomography
2013
Imaging Glutamate Homeostasis in Cocaine Addiction with the Metabotropic Glutamate Receptor 5 Positron Emission Tomography Radiotracer [11C]ABP688 and Magnetic Resonance Spectroscopy
Martinez D, Slifstein M, Nabulsi N, Grassetti A, Urban NB, Perez A, Liu F, Lin SF, Ropchan J, Mao X, Kegeles LS, Shungu DC, Carson RE, Huang Y. Imaging Glutamate Homeostasis in Cocaine Addiction with the Metabotropic Glutamate Receptor 5 Positron Emission Tomography Radiotracer [11C]ABP688 and Magnetic Resonance Spectroscopy. Biological Psychiatry 2013, 75: 165-171. PMID: 24035345, PMCID: PMC4106018, DOI: 10.1016/j.biopsych.2013.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCarbon RadioisotopesCase-Control StudiesChoice BehaviorCocaineCocaine-Related DisordersCorpus StriatumFunctional NeuroimagingGlutamic AcidGlutamineHomeostasisHumansMagnetic Resonance SpectroscopyMaleOximesPositron-Emission TomographyPyridinesReceptor, Metabotropic Glutamate 5Self AdministrationYoung AdultConceptsHealthy control subjectsCocaine addictionControl subjectsLong-term cocaine useMagnetic resonance spectroscopy measuresGlutamate-glutamine levelsMGluR5 receptor bindingCocaine self-administration sessionsPositron emission tomography (PET) radiotracerPositron emission tomographySelf-administration sessionsCocaine-seeking behaviorSelf-administer cocaineMGluR5 bindingMGluR5 availabilityLeft striatumCocaine exposurePreclinical studiesGlutamate homeostasisGlutamate turnoverSubcortical regionsStriatumCocaine useMagnetic resonance spectroscopySecondary analysis