2017
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Science Translational Medicine 2017, 9 PMID: 28148839, PMCID: PMC5435119, DOI: 10.1126/scitranslmed.aal2463.Peer-Reviewed Original ResearchConceptsIsocitrate dehydrogenase 1PARP inhibitor sensitivityPossible therapeutic strategiesHomologous recombination defectsTherapeutic strategiesTumor xenograftsInhibitor sensitivityPathologic processesSmall molecule inhibitorsIDH1/2 mutationsTumor progressionIDH2 mutationsMutant IDHPolymerase inhibitorsGlioma cellsTumor cellsHR deficiencyPARP inhibitionIDH mutationsInhibitory effectDehydrogenase 1Neomorphic activityMutant IDH1 enzymeDependent dioxygenasesMutant cells
2007
GENETICS OF INTRACRANIAL ANEURYSMS
Nahed BV, Bydon M, Ozturk AK, Bilguvar K, Bayrakli F, Gunel M. GENETICS OF INTRACRANIAL ANEURYSMS. Neurosurgery 2007, 60: 213-226. PMID: 17290171, DOI: 10.1227/01.neu.0000249270.18698.bb.Peer-Reviewed Original ResearchConceptsIntracranial aneurysmsRisk factorsPatient-specific risk factorsGenetic susceptibilityAneurysmal subarachnoid hemorrhageHigh-risk individualsSpecific risk factorsIA pathogenesisNovel therapeutic strategiesRupture of aneurysmsDiagnosis of IAAsymptomatic patientsMedical comorbiditiesFormation of IAsPoor prognosisSubarachnoid hemorrhageEarly diagnosisEpidemiological studiesTherapeutic strategiesPreclinical settingDisease pathophysiologyOverall outcomePatientsAneurysmsModest improvement
1998
Molecular Biology of Cerebrovascular Diseases
Gunel M, Awad I, Lifton R. Molecular Biology of Cerebrovascular Diseases. 1998, 163-173. DOI: 10.1007/978-1-4613-9350-4_15.Peer-Reviewed Original ResearchMolecular biologyIdentification of genesCerebrovascular diseaseMolecular geneticsMolecular mechanismsScope of neurosurgeryNovel therapeutic strategiesBiologyNew insightsPathologic angiogenesisInherited predispositionTherapeutic strategiesBasic mechanismsPreclinical diagnosisDiseaseGenesGeneticsMechanismAngiogenesisIschemiaPatientsPathophysiologyPathogenesisNew opportunitiesDiagnosis