2022
Hormone therapies in meningioma-where are we?
Miyagishima D, Moliterno J, Claus E, Günel M. Hormone therapies in meningioma-where are we? Journal Of Neuro-Oncology 2022, 161: 297-308. PMID: 36418843, PMCID: PMC10371392, DOI: 10.1007/s11060-022-04187-1.Peer-Reviewed Original ResearchConceptsPositive receptor statusReceptor statusSomatostatin analoguesClinical trialsHormone-related risk factorsMajority of patientsNIH Clinical Trials DatabaseClinical trials databasesStratification of patientsHormone therapyTrials databasesFuture trialsHormonal agentsSpecific therapyRisk factorsSomatostatin receptorsInclusion criteriaMEDLINE-PubMedMeningioma growthMost meningiomasTherapeutic potentialMeningiomasPatientsTherapyTrials
2021
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient population
2020
Clinical and genomic factors associated with seizures in meningiomas.
Gupte TP, Li C, Jin L, Yalcin K, Youngblood MW, Miyagishima DF, Mishra-Gorur K, Zhao AY, Antonios J, Huttner A, McGuone D, Blondin NA, Contessa JN, Zhang Y, Fulbright RK, Gunel M, Erson-Omay Z, Moliterno J. Clinical and genomic factors associated with seizures in meningiomas. Journal Of Neurosurgery 2020, 135: 835-844. PMID: 33276341, DOI: 10.3171/2020.7.jns201042.Peer-Reviewed Original ResearchPreoperative seizuresPostoperative seizuresAtypical histologyMultivariate analysisWorse progression-free survivalGenomic subgroupsYale-New Haven HospitalAssociation of seizuresAntiepileptic drug useProgression-free survivalSeizure-free patientsGross total resectionExtent of resectionMultiple risk factorsNF2 mutationsNew Haven HospitalLogistic regression modelsPostoperative radiationSeizure freedomClinical courseSeizure presentationSomatic NF2 mutationsBrain invasionRecurrent tumorsRisk factors
2012
Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure
Gaál EI, Salo P, Kristiansson K, Rehnström K, Kettunen J, Sarin AP, Niemelä M, Jula A, Raitakari OT, Lehtimäki T, Eriksson JG, Widen E, Günel M, Kurki M, von und zu Fraunberg M, Jääskeläinen JE, Hernesniemi J, Järvelin MR, Pouta A, , Newton-Cheh C, Salomaa V, Palotie A, Perola M. Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure. PLOS Genetics 2012, 8: e1002563. PMID: 22438818, PMCID: PMC3305343, DOI: 10.1371/journal.pgen.1002563.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureChromosomes, Human, Pair 5Cohort StudiesFemaleFinlandGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIntracranial AneurysmMaleMiddle AgedMuscle ProteinsMyocytes, Smooth MusclePolymorphism, Single NucleotideRisk FactorsTranscription FactorsZinc FingersConceptsSystolic blood pressureBlood pressureSystolic BPRisk factorsIntracranial aneurysmsElevated systolic blood pressurePopulation-based Finnish cohortsDiastolic blood pressureHigher systolic BPMean arterial pressureTraditional risk factorsVascular smooth muscle cellsStrong risk factorCommon risk factorsQuantitative outcome variablesVascular wall structureSmooth muscle cellsGenome-wide association studiesArterial pressureCerebral arteryPulse pressureFinnish cohortComplex diseasesMuscle cellsRisk alleles
2007
GENETICS OF INTRACRANIAL ANEURYSMS
Nahed BV, Bydon M, Ozturk AK, Bilguvar K, Bayrakli F, Gunel M. GENETICS OF INTRACRANIAL ANEURYSMS. Neurosurgery 2007, 60: 213-226. PMID: 17290171, DOI: 10.1227/01.neu.0000249270.18698.bb.Peer-Reviewed Original ResearchConceptsIntracranial aneurysmsRisk factorsPatient-specific risk factorsGenetic susceptibilityAneurysmal subarachnoid hemorrhageHigh-risk individualsSpecific risk factorsIA pathogenesisNovel therapeutic strategiesRupture of aneurysmsDiagnosis of IAAsymptomatic patientsMedical comorbiditiesFormation of IAsPoor prognosisSubarachnoid hemorrhageEarly diagnosisEpidemiological studiesTherapeutic strategiesPreclinical settingDisease pathophysiologyOverall outcomePatientsAneurysmsModest improvement
2005
Hypertension, age, and location predict rupture of small intracranial aneurysms.
Nahed BV, DiLuna ML, Morgan T, Ocal E, Hawkins AA, Ozduman K, Kahle KT, Chamberlain A, Amar AP, Gunel M. Hypertension, age, and location predict rupture of small intracranial aneurysms. Neurosurgery 2005, 57: 676-83; discussion 676-83. PMID: 16239879, DOI: 10.1227/01.neu.0000175549.96530.59.Peer-Reviewed Original ResearchConceptsUnruptured intracranial aneurysmsRisk factorsIntracranial aneurysmsSubarachnoid hemorrhageUnruptured aneurysmsMinimal long-term morbidityHistory of hypertensionNormal blood pressureLong-term morbidityTertiary medical centerAge of patientsAnterior circulation aneurysmsPosterior circulation aneurysmsSignificant risk factorsSignificant independent predictorsRupture of IAsMortality of treatmentLogistic regression modelsSmall intracranial aneurysmsHypertensive patientsIndependent predictorsPosterior circulationBlood pressureAneurysm characteristicsCurrent guidelines