2018
De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus
Furey CG, Choi J, Jin SC, Zeng X, Timberlake AT, Nelson-Williams C, Mansuri MS, Lu Q, Duran D, Panchagnula S, Allocco A, Karimy JK, Khanna A, Gaillard JR, DeSpenza T, Antwi P, Loring E, Butler WE, Smith ER, Warf BC, Strahle JM, Limbrick DD, Storm PB, Heuer G, Jackson EM, Iskandar BJ, Johnston JM, Tikhonova I, Castaldi C, López-Giráldez F, Bjornson RD, Knight JR, Bilguvar K, Mane S, Alper SL, Haider S, Guclu B, Bayri Y, Sahin Y, Apuzzo MLJ, Duncan CC, DiLuna ML, Günel M, Lifton RP, Kahle KT. De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus. Neuron 2018, 99: 302-314.e4. PMID: 29983323, PMCID: PMC7839075, DOI: 10.1016/j.neuron.2018.06.019.Peer-Reviewed Original ResearchConceptsCongenital hydrocephalusNeural stem cell fateHuman congenital hydrocephalusDamaging de novoCerebrospinal fluid homeostasisSubstantial morbidityCH patientsTherapeutic ramificationsSignificant burdenBrain ventriclesCH pathogenesisNeural tube developmentFluid homeostasisDe novo mutationsExome sequencingAdditional probandsHydrocephalusPathogenesisNovo mutationsNovo duplicationProbandsDe novoCell fateMorbidityPatients
2000
Carotid Endarterectomy Prevention Strategies and Complications Management
Gunel M, Awad I. Carotid Endarterectomy Prevention Strategies and Complications Management. Neurosurgery Clinics Of North America 2000, 11: 351-364. PMID: 10733850, DOI: 10.1016/s1042-3680(18)30137-2.Peer-Reviewed Original ResearchConceptsCarotid endarterectomyAppropriate patient selectionCarotid occlusive diseaseLow complication ratePerioperative complicationsPerioperative courseComplication rateIntraoperative complicationsOcclusive diseaseSurgical treatmentPatient selectionPostoperative careComplication managementPrevention strategiesCareful assessmentComplicationsEndarterectomyMorbidityPatientsDiseaseCarePrevention