2020
Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis
Valenzuela A, Baron M, Rodriguez-Reyna TS, Proudman S, Khanna D, Young A, Hinchcliff M, Steen V, Gordon J, Hsu V, Castelino FV, Schoenfeld S, Li S, Wu JY, Fiorentino D, Chung L. Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis. Seminars In Arthritis And Rheumatism 2020, 50: 891-896. PMID: 32898758, PMCID: PMC8205269, DOI: 10.1016/j.semarthrit.2020.06.007.Peer-Reviewed Original ResearchConceptsSSc patientsSystemic sclerosisDigital ischemiaHealth Assessment Questionnaire Disability IndexCochin Hand Functional ScaleACR/EULAR criteriaSubcutaneous calcium depositionConsecutive SSc patientsSubset of patientsMedian T-scoreDisability IndexFinger/thumbCommon complicationDisease durationEULAR criteriaIschemic manifestationsAcro-osteolysisMultivariable analysisPhysical examinationHand functionClinical correlationHand dysfunctionClear historyHigh burdenBone densitometry
2016
Molecular Stratification by Gene Expression as a Paradigm for Precision Medicine in Systemic Sclerosis
Hinchcliff M, Whitfield M. Molecular Stratification by Gene Expression as a Paradigm for Precision Medicine in Systemic Sclerosis. 2016, 657-670. DOI: 10.1007/978-3-319-31407-5_49.Peer-Reviewed Original ResearchSystemic sclerosisPatient subsetsProgressive interstitial lung diseaseDiffuse cutaneous systemic sclerosisAppropriate patient subsetsScleroderma renal crisisCutaneous systemic sclerosisInvestigator-initiated trialPulmonary arterial hypertensionSubset of patientsDifferent patient subsetsInterstitial lung diseaseDifferent pathophysiological processesMolecular pathwaysPrecision medicineGene expression subsetsT lymphocyte activationUninvolved skin samplesInflammatory subsetRenal crisisSSc complicationsArterial hypertensionMycophenolate mofetilClinical improvementOrgan involvement