2020
Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis
Valenzuela A, Baron M, Rodriguez-Reyna TS, Proudman S, Khanna D, Young A, Hinchcliff M, Steen V, Gordon J, Hsu V, Castelino FV, Schoenfeld S, Li S, Wu JY, Fiorentino D, Chung L. Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis. Seminars In Arthritis And Rheumatism 2020, 50: 891-896. PMID: 32898758, PMCID: PMC8205269, DOI: 10.1016/j.semarthrit.2020.06.007.Peer-Reviewed Original ResearchConceptsSSc patientsSystemic sclerosisDigital ischemiaHealth Assessment Questionnaire Disability IndexCochin Hand Functional ScaleACR/EULAR criteriaSubcutaneous calcium depositionConsecutive SSc patientsSubset of patientsMedian T-scoreDisability IndexFinger/thumbCommon complicationDisease durationEULAR criteriaIschemic manifestationsAcro-osteolysisMultivariable analysisPhysical examinationHand functionClinical correlationHand dysfunctionClear historyHigh burdenBone densitometry
2015
Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures
Taroni JN, Martyanov V, Huang CC, Mahoney JM, Hirano I, Shetuni B, Yang GY, Brenner D, Jung B, Wood TA, Bhattacharyya S, Almagor O, Lee J, Sirajuddin A, Varga J, Chang RW, Whitfield ML, Hinchcliff M. Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures. Arthritis Research & Therapy 2015, 17: 194. PMID: 26220546, PMCID: PMC4518531, DOI: 10.1186/s13075-015-0695-1.Peer-Reviewed Original ResearchConceptsSystemic sclerosisEsophageal biopsiesInflammatory signatureLarge inflammatory infiltratesConsecutive SSc patientsSmooth muscle atrophyAbsence of fibrosisSmooth muscle functionProliferative gene expression signatureGene expression subsetsSmooth muscle cellsEsophageal dilatationGene expression signaturesSSc patientsEsophageal fibrosisSerum autoantibodiesInflammatory infiltrateEsophageal pathologyImmune activationAutopsy studySSc pathogenesisSSc casesMolecular subsetsGene expressionMuscle atrophy