2016
Modulatory compartments in cortex and local regulation of cholinergic tone
Coppola JJ, Ward NJ, Jadi MP, Disney AA. Modulatory compartments in cortex and local regulation of cholinergic tone. Journal Of Physiology-Paris 2016, 110: 3-9. PMID: 27553093, PMCID: PMC5164978, DOI: 10.1016/j.jphysparis.2016.08.001.Peer-Reviewed Original ResearchConceptsCholinergic modulationCortical circuitsLocal cortical circuitsSubcellular receptor localizationCholinergic toneCholinergic systemReceptor expressionAxonal innervationModulatory inputsVisual pathwayLocal circuitsCortical tissueNeuromodulatory signalingReceptor localizationNeuromodulatory toneCortexPathological statesLocal regulationModulatory signalsExistence of compartmentsCompartmentsToneSpecific responsesSignalingInnervation
2015
Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia
Jadi MP, Behrens MM, Sejnowski TJ. Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia. Biological Psychiatry 2015, 79: 716-726. PMID: 26281716, PMCID: PMC4720598, DOI: 10.1016/j.biopsych.2015.07.005.Peer-Reviewed Original ResearchConceptsInhibitory neuronsGamma-band oscillationsNMDAR hypofunctionAnimal modelsN-methyl-D-aspartate (NMDA) receptor hypofunctionParvalbumin-expressing inhibitory neuronsAbnormal gamma oscillationsReceptor hypofunctionNMDAR antagonistsHypofunctionVisual cortexSZ symptomsSchizophreniaGamma oscillationsGenetic knockoutHuman subjectsBand oscillationsSymptomsNeuronsMagnetoencephalography (MEG) signalsPatientsAntagonistN-methylCortexNeuropharmacology