Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia
Jadi MP, Behrens MM, Sejnowski TJ. Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia. Biological Psychiatry 2015, 79: 716-726. PMID: 26281716, PMCID: PMC4720598, DOI: 10.1016/j.biopsych.2015.07.005.Peer-Reviewed Original ResearchConceptsInhibitory neuronsGamma-band oscillationsNMDAR hypofunctionAnimal modelsN-methyl-D-aspartate (NMDA) receptor hypofunctionParvalbumin-expressing inhibitory neuronsAbnormal gamma oscillationsReceptor hypofunctionNMDAR antagonistsHypofunctionVisual cortexSZ symptomsSchizophreniaGamma oscillationsGenetic knockoutHuman subjectsBand oscillationsSymptomsNeuronsMagnetoencephalography (MEG) signalsPatientsAntagonistN-methylCortexNeuropharmacology